DNA Damage/DNA Repair

DBCO-PEG3-GGFG-Exatecan is a Drug-linker conjugate for ADC.

SYS6010 is an antibody-drug conjugate (ADC) targeting epidermal growth factor receptor ( EGFR ), which is formed by conjugating the anti-EGFR humanized IgG1 monoclonal antibody Becotatug with the topoisomerase I inhibitor JS-1 via a cleavable tetrapeptide linker.

TQB2102 is a bispecific epitope antibody-drug conjugate targeting HER2, composed of the antibody Rolditamig and the toxin molecule Deruxtecan-d 2.

Zocilurtatug pelitecan (ZL-1310) is a blood-brain barrier-penetrating antibody-drug conjugate targeting DLL3.

Anisomelic acid is a human papillomavirus HPV16 E6 and HPV E7 depletor.

DNA polymerase-IN-6 formic is an antiviral agent and a DNA polymerase inhibitor.

(R)-Adibelivir ((R)-IM-250) is a blood-brain barrier-permeable HSV helicase-primase inhibitor.

Anti-Influenza agent 10 (Compound 41) is an influenza A virus RNA-dependent RNA polymerase ( RdRp ) inhibitor.

Parthenin is a pseudoguaianolide-type sesquiterpene lactone present in Parthenium hysterophorus L.

Nicoxamat (N-Hydroxynicotinamide) is a HCV inhibitor as well as a selective HDAC6 inhibitor.

MYCMI-7 hydrobromide is a potent and selective MYC/MYCN inhibitor, with a K d of 4 μM for MYC and an IC 50 of 10 μM for topoisomerase IIα ( Topoisomerase II α ).

(2S,3R,4S)-ASX-173 is the (2S,3R,4S)-enantiomer of ASX-173.

TMLB-C16 is a potent and orally active B3GAT3 inhibitor with a K D of 3.962 μM.

GPS167 is a CLK kinase inhibitor that potently and selectively inhibits recombinant human CLK1, CLK2 and CLK4.

MS1129 is a DNMT degrader that induces proteasomal degradation of DNMT1, DNMT3A and DNMT3B proteins.

4,8-DiMeIQx is an orally active mutagen, selective dopaminergic neurotoxicant, and DNA damaging agent.

Bleomycin B2 (Phleomycin D2) sulfate is a selective antitumor and antibacterial agent that induces DNA strand breaks and inhibits DNA ligase activity.

CTX-439 is an orally active, ATP-competitive small-molecule inhibitor of CDK12 and CDK13, with an IC 50 of 3.1 nM and a K d of 0.38 nM against CDK12, and an IC 50 of 9.2 nM against CDK13.

CID-078 is an orally active macrocyclic cyclin A and cyclin B inhibitor.

Q901 (CDK7-IN-21) TFA is a selective and potent CDK7 inhibitor with an IC 50 of 10 nM.

SY-589 is an orally active DNA polymerase Polθ helicase domain inhibitor ( IC 50 =2.29 nM) and DNA damage inducer.

C791-0064 is a RAD52 inhibitor.

WCY-8-67 TFA is an orally active and selective USP5 inhibitor, with an IC 50 value of 1.33 μM.

AP232 dihydrochloride is a selective U2AF1-UHM Inhibitor with an IC 50 of 7.96 μM.