DNA Damage/DNA Repair
Research Areas
- MTH1(4)
- PARP(103)
- ATM/ATR(31)
- DNA Alkylating(23)
- DNA Ligases(3)
- DNA Methyltransferase(27)
- DNA-PK(28)
- HDAC(143)
- Nucleoside Antimetabolite/Analogue(194)
- Telomerase(15)
- Topoisomerase(193)
- tankyrase(5)
- Antifolate(33)
- CDK(299)
- Checkpoint Kinase (Chk)(36)
- CRISPR/Cas9(9)
- Deubiquitinase(84)
- DNA Alkylator/Crosslinker(87)
- DNA/RNA Synthesis(575)
- Eukaryotic Initiation Factor (eIF)(33)
- IRE1(25)
- LIM Kinase (LIMK)(12)
- TOPK(6)
- Casein Kinase(59)
- DNA Intercalating Agents(8)
- DNA/RNA Oxidative Damage(13)
- Poly(ADP-ribose) Glycohydrolase (PARG)(5)
- Early 2 Factor (E2F)(2)
- Zinc Finger Protein(1)
Products Related to DNA Damage/DNA Repair(1968)
- GC79006CDK2 degrader 8CAS: 3099145-52-2Purity: >98%
CDK2 degrader 8 is a selective cyclin-dependent kinase 2 ( CDK2 ) degrader.
- GC79007Cdk2/Cyclin Inhibitory Peptide I acetatePurity: >99.50%
Cdk2/Cyclin Inhibitory Peptide I (Tat-LFG) acetate, a CDK2 inhibitor, kills U2OS osteosarcoma cells in a dose-dependent manner [1] .
- GC790212-Amino-3-methylimidazo[4,5-f]quinoxalineCAS: 108354-47-8Purity: >96.00%
2-Amino-3-Methylimidazo[4,5-f]quinoxaline is a food mutagen with mutagenic activity.
- GC79023N-NitrosoatrazineCAS: 56525-09-8Purity: >98%
N-Nitrosoatrazine is an Atrazine nitrosation product.
- GC790275'-Amino-modifier C3-TFACAS: 853955-89-2Purity: >98%
5'-Amino-modifier C3-TFA is a phosphoramidite that can be used in the synthesis of oligonucleotides.
- GC79030CHD1L-IN-2CAS: 1251542-88-7Purity: >98%
CHD1L-IN-2 is a CHD1L inhibitor and exhibits cytotoxicity against tumor cells [1] [2] .
- GC79033ALC1-IN-1 free baseCAS: 2781958-38-9Purity: >98.00%
ALC1-IN-1 (compound 1) free base is an ALC1 inhibitor in crystalline form that can be used in the research of cancer [1] .
- GC79036RG3039 hydrochlorideCAS: 1466525-84-7Purity: >98.00%
RG3039 hydrochloride is an orally active, blood-brain barrier-permeable DcpS inhibitor with an IC 50 of 4.2 nM against hDcpS.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC79006 | CDK2 degrader 8 | 3099145-52-2 | >98% | |
CDK2 degrader 8 is a selective cyclin-dependent kinase 2 ( CDK2 ) degrader. | ||||
| GC79007 | Cdk2/Cyclin Inhibitory Peptide I acetate | - | >99.50% | |
Cdk2/Cyclin Inhibitory Peptide I (Tat-LFG) acetate, a CDK2 inhibitor, kills U2OS osteosarcoma cells in a dose-dependent manner [1] . | ||||
| GC79018 | MS8572 | 3060517-63-4 | >98% | |
MS8572 is a selective OTUB1 covalent ligand. | ||||
| GC79019 | Huib32 | - | >98.50% | |
Huib32 is a potent small-molecule inhibitor of USP32 ( IC 50 = 21.2 nM), exhibiting high selectivity over other closely related deubiquitinating enzymes (DUBs), such as USP8/10/16, UCHL1 and OTUB2. | ||||
| GC79020 | CAS-010 | 3094094-17-1 | >98% | |
CAS-010 (CAS-13312-010) is a potent and selective USP28 inhibitor with an IC 50 of 2.2 nM against full-length USP28. | ||||
| GC79021 | 2-Amino-3-methylimidazo[4,5-f]quinoxaline | 108354-47-8 | >96.00% | |
2-Amino-3-Methylimidazo[4,5-f]quinoxaline is a food mutagen with mutagenic activity. | ||||
| GC79022 | Amidox | 95933-72-5 | >98.00% | |
Amidox is a ribonucleotide reductase inhibitor. | ||||
| GC79023 | N-Nitrosoatrazine | 56525-09-8 | >98% | |
N-Nitrosoatrazine is an Atrazine nitrosation product. | ||||
| GC79024 | DHPS-IN-3 | 2470012-40-7 | >98.00% | |
DHPS-IN-3 (Compound 26d) is a NAD-competitive DHPS inhibitor, with an IC 50 of 0.0092 μM at 14 μM NAD and an IC 50 of 0.069 μM at 250 μM NAD. | ||||
| GC79025 | NFYi5 | 925644-66-2 | >97.00% | |
NFYi5 is a nuclear transcription factor-Y ( NF-Y ) inhibitor. | ||||
| GC79026 | SH-0029 | 2869231-20-7 | >98% | |
SH-0029 is a SOX10 inhibitor with activity against melanoma. | ||||
| GC79027 | 5'-Amino-modifier C3-TFA | 853955-89-2 | >98% | |
5'-Amino-modifier C3-TFA is a phosphoramidite that can be used in the synthesis of oligonucleotides. | ||||
| GC79028 | DHX8-IN-1 | - | >98% | |
DHX8-IN-1 is a DHX8 inhibitor with an IC 50 of 40 nM in ATPase activity assays. | ||||
| GC79029 | S,S-DACH-Pt-SO4 | 66900-71-8 | >98% | |
S,S-DACH-Pt-SO4 is a platinum based drug. | ||||
| GC79030 | CHD1L-IN-2 | 1251542-88-7 | >98% | |
CHD1L-IN-2 is a CHD1L inhibitor and exhibits cytotoxicity against tumor cells [1] [2] . | ||||
| GC79031 | nTRD22 | 1065567-62-5 | >95.00% | |
nTRD22 is an RNA-binding allosteric modulator targeting TDP-43. | ||||
| GC79032 | IAG-10 | 2361305-69-1 | >99.50% | |
IAG-10 is a selective DNA polymerase kappa ( hpol κ ) inhibitor with an IC 50 value of 7.2 μM. | ||||
| GC79033 | ALC1-IN-1 free base | 2781958-38-9 | >98.00% | |
ALC1-IN-1 (compound 1) free base is an ALC1 inhibitor in crystalline form that can be used in the research of cancer [1] . | ||||
| GC79034 | Zelpolib | 701932-26-5 | >98.50% | |
Zelpolib is a non-competitive Pol δ inhibitor. | ||||
| GC79035 | NP1867 | 2930070-08-7 | >99.50% | |
NP1867 is a potent, selective, covalent PMS2 inhibitor. | ||||
| GC79036 | RG3039 hydrochloride | 1466525-84-7 | >98.00% | |
RG3039 hydrochloride is an orally active, blood-brain barrier-permeable DcpS inhibitor with an IC 50 of 4.2 nM against hDcpS. | ||||
| GC79037 | AZD4956 | 3045469-78-8 | >98% | |
AZD4956 is a potent and selective DNA polymerase theta (POLQ) inhibitor. | ||||
| GC79038 | FRC-222 | - | >98.50% | |
FRC-222 is a CHD1 tandem chromodomain inhibitor with a K d of 0.15 μM and an IC 50 of 0.18 μM. | ||||
| GC79039 | FRC-303 | - | >98% | |
FRC-303 is a CHD1 inhibitor with a K d of 0.14 μM and an IC 50 of 0.18 μM. | ||||