Proteases

IM176OUT05 is a highly soluble biguanide. It activates stem cell metabolism, promotes hair regeneration, and increases the induction and maintenance of stemness during pluripotent stem cell generation. IM176OUT05 inhibits electron transport chain (ETC) activity in mitochondria with an IC50 of 3.2 μM.

JG-231 is a JG-98 analogue with anti-cancer properties. It can inhibit the interaction between Hsp70-BAG3. JG-231 has an inhibitory effect on the MDA-MB-231 xenograft model of triple-negative breast cancer (TNBC).

JO146 is a proteinase inhibitor of Chlamydia trachomatis high-temperature requirement A (CtHtrA) required for inclusion formation, with IC50 values of 21.86 and 1.15 μM against CtHtrA and human neutrophil elastase (HNE), respectively. JO146 can be used to inhibit bacterial infections.

KKII5 is an effective lipoxygenase LOX-1 inhibitor with an IC50 of 19 μM. KKII5 inhibits lipid peroxidation.

KS100 is an effective ALDH inhibitor with IC50 values of 334, 2137, and 360 nM for ALDH1A1, ALDH2, and ALDH3A1 respectively. It has low toxicity and exhibits anti-proliferative and anti-cancer effects. KS100 significantly increases ROS activity, lipid peroxidation, and accumulation of toxic aldehydes. KS100 induces apoptosis and cell cycle arrest at the G2/M phase.

L-5-Hydroxytryptophan-d3 is the deuterated form of L-5-Hydroxytryptophan. L-5-Hydroxytryptophan (L-5-HTP) is a natural amino acid and dietary supplement that can act as an antidepressant, appetite suppressant, and sleep aid. It is a precursor to the neurotransmitter serotonin and an antagonist of reserpine. L-5-Hydroxytryptophan (L-5-HTP) has been studied for fibromyalgia, muscle spasms, migraines, and cerebellar ataxia.

L-Alanine-13C2,15N is L-Alanine labeled with 13C and 15N. L-Alanine is a non-essential amino acid that can participate in sugar and acid metabolism, enhance immunity, and provide energy for muscle tissue, the brain, and central nervous system.

L-Asparagine-13C4,15N2,d8 is a labeled form of L-Asparagine with 13C and 15N isotopes. L-Asparagine ((-)-Asparagine) is a nonessential amino acid that participates in metabolic control of nerve and brain tissue cell functions.

L-Citrulline-d7 is the deuterated form of L-Citrulline. L-Citrulline is an amino acid that originates from ornithine, a byproduct of the breakdown of proline, glutamine, and glutamate salts, or obtained through the arginine-citrulline pathway from l-arginine.

L-Histidine-d5 (hydrochloride hydrate) is the deuterated form of L-Histidine hydrochloride hydrate. L-Histidine hydrochloride hydrate (H-His-OH.HCl.H2O) is an endogenous metabolic product.

Lichenase (endo-1,3:1,4-β-D-glucanase) is a specific endo-hydrolysis enzyme that cleaves (1-3),(1-4)-β-D-glucans into oligosaccharides. Lichenase dissolves β-glucans in grains and produces galactooligosaccharides (GOS). Lichenase can be used to degrade polysaccharides in cell walls.

Lignoceric acid-d4-2 is the deuterated form of Lignoceric acid. Lignoceric acid (Tetracosanoic acid) is a 24-carbon saturated (24:0) fatty acid synthesized in developing brains and also a byproduct of lignin production. Lignoceric acid can be used for research on Zellweger syndrome, cerebral adrenoleukodystrophy, and other conditions related to brain and liver function.

Lignoceric acid-d9 is the deuterated form of Lignoceric acid. Lignoceric acid (Tetracosanoic acid) is a 24-carbon saturated (24:0) fatty acid synthesized in the developing brain and also a byproduct of lignin production. Lignoceric acid can be used for research on Zellweger syndrome, cerebral adrenoleukodystrophy, and other conditions related to brain and liver function.

L-Lysine-13C6 (dihydrochloride) is a labeled form of L-Lysine dihydrochloride with 13C. L-lysine dihydrochloride is an essential amino acid for humans and has various benefits, including its use in herpes research, increasing calcium absorption, reducing diabetes-related diseases, and improving gut health.

L-Methionine-13C5 is a labeled form of L-Methionine with 13C. L-Methionine is the L-isomer of Methionine, which is an essential amino acid. Methionine acts as a strong liver detoxifier and serves as a liver protectant.

Lonodelestat TFA (POL6014 TFA) is an effective, orally active, selective peptide inhibitor of human neutrophil elastase (hNE). Lonodelestat TFA has potential for research in cystic fibrosis (CF).

L-Ornithine-d2 (hydrochloride) is the deuterated form of L-Ornithine hydrochloride. L-Ornithine hydrochloride is a free amino acid that plays an important role in the urea cycle and is also important for processing excess nitrogen.

L-Serine-13C is L-Serine with a 13C label. L-Serine ((-)-Serine; (S)-Serine) is a nonessential amino acid that plays an important role in cell proliferation.

L-Tryptophan-d3 is a deuterated form of L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid and a precursor to serotonin, melatonin, and vitamin B3.

L-Tyrosine-3,5-13C2 is a labeled form of L-Tyrosine with 13C. L-Tyrosine is a nonessential amino acid that can inhibit the activity of citrate synthase in the posterior cortex.

L-Tyrosine-d5 is a deuterated form of L-Tyrosine. L-Tyrosine is a non-essential amino acid that can inhibit the activity of citrate synthase in the posterior cortex.

Lyciumin A is a cyclic octapeptide that exhibits inhibitory activity against proteases, renin, and angiotensin-converting enzyme. Lyciumin A can be used for research on hypertension.

M4K2234 (compound 26b) is an inhibitor of ALK2. M4K2234 inhibits ALK2 and ALK5 with IC50 values of 5 and 2144 nM, respectively. M4K2234 can be used as a chemical probe for the protein kinases ALK1 and ALK2. M4K2234 can be used in cancer research.

MAL3-101 is an effective inhibitor of heat shock protein 70 (HSP70) conformational changes. MAL3-101 inhibits HSP70 ATPase activity by blocking the interaction of Hsp40 molecular chaperones. MAL3-101 can be used for research on invasive bladder cancer.