Metabolism
- Sterol Biosynthesis(26)
- PPAR(183)
- 5-alpha Reductase(9)
- 5-Lipoxygenase(11)
- Adenosine Deaminase(6)
- Aminopeptidase(7)
- C14ɑ demethylase(2)
- Carbonic Anhydrase(56)
- CETP(9)
- Cholesterol absorption(1)
- CPT1(2)
- CYP3A/CYP450(22)
- Dehydrogenase(132)
- DHFR(6)
- DGAT(8)
- Dopamine β-hydroxylase(10)
- Enolase(11)
- FAAH(34)
- Factor Xa(41)
- Ferroptosis(159)
- Folate Analogue(2)
- Glucokinase(17)
- HLE(0)
- HMG-CoA Reductase(34)
- HSP(59)
- IDO(45)
- KRAS-PDEδ(3)
- MAO(6)
- Metabolic Enzymes(0)
- Neuronal Metabolism(8)
- Oxidative Phosphorylation(17)
- P450(120)
- PDE(223)
- Phospholipase(113)
- Procollagen C Proteinase(1)
- Saccharometabolism(1)
- SCD(16)
- SGLT(26)
- TPH(4)
- Transferase(177)
- Energy Metabolism(0)
- Inorganic Ions(0)
- ALP(1)
- Carbohydrates(18)
- Uric Acid(0)
- Muscle Metabolism(0)
- MDA(0)
- MPO(0)
- Transaminase(20)
- Glutathione Reductase(0)
- Thioredoxin Reductase(0)
- Catalase(8)
- monooxygenase(1)
- PKM2(1)
- aldehyde dehydrogenase(1)
- Squalene synthase(1)
- Hydrolase(47)
- ornithine decarboxylase(1)
- Amino acid metabolism(3)
- phosphatases(92)
- Pyruvate kinase(8)
- Others(4)
- MGL(1)
- Galactosidase(6)
- 12-Lipoxygenase(1)
- Fatty Acid Synthase (FASN)(9)
- Dihydroorotate Dehydrogenase(12)
- Bile Acids & Microbiome(94)
- Bone Growth & Remodeling(35)
- Carbohydrate Metabolism(126)
- Cofactors & Vitamins(64)
- Dyslipidemias(73)
- Inborn Errors of Metabolism(80)
- Metabolic Syndrome(16)
- Necroptosis(10)
- Necrosis(15)
- Nutrient Sensing(12)
- Phosphodiesterase(27)
- Reproductive Biology(126)
- Thermogenesis(6)
- Prolyl Hydroxylation Enzymes(1)
- Biliary System(4)
- Metabolic Disease(4)
- Fat Mass and Obesity-associated Protein (FTO)(2)
- SHIP(1)
Products for Metabolism
- Cat.No. Nombre del producto Información
- GC66197 α-?Terpinyl acetate α-El acetato de terpinilo es un éster de monoterpeno aislado del aceite esencial de Laurus nobilis L. α-El acetato de terpinilo es un sustrato competitivo de P450 2B6 que se une al sitio activo de P450 2B6 con un valor Kd de 5,4μM.
-
GC11123
α-CEHC
γTocopherol Metabolite, GTM, 2,7,8trimethyl2(βCarboxyEthyl)6Hydroxychroman
A major metabolite of δ-tocopherol -
GC48276
α-Cyclodextrin (hydrate)
α-CD, NSC 269470, Schardinger α-Dextrin
A cyclic hexasaccharide -
GC48278
α-D-Glucose-1,6-bisphosphate (potassium salt hydrate)
D-Glucose-1,6-diphosphate
A bis-phosphorylated derivative of α-D-glucose -
GC48279
α-D-Glucose-1-phosphate (sodium salt hydrate)
α-D-Glc 1-P
An intermediate in glycogen metabolism -
GC52253
α-Enolase (1-19)-biotin Peptide
Enolase-1 (1-19)-biotin
A biotinylated α-enolase peptide - GC45208 α-hydroxy Metoprolol α-hydroxy Metoprolol is an active metabolite of the β1-adrenergic receptor blocker metoprolol.
-
GC45210
α-Linolenic Acid (sodium salt)
ALA, C18:3 (9Z,12Z,15Z), C18:3 n-3
α-Linolenic acid (ALA) is an essential fatty acid found in leafy green vegetables. -
GC48283
α-Linolenic Acid-d14
ALAd14
An internal standard for the quantification of αLinolenic acid -
GC45602
α-Linolenic Acid-d5 MaxSpec• Standard
ALA-d5, C18:3 (9Z,12Z,15Z)-d5, C18:3 n-3-d5
-
GC49008
α-Muricholic Acid-d4
ω-MCA-d4
An internal standard for the quantification of α-muricholic acid -
GC40480
α-Phenyl-α-(2-pyridyl)acetonitrile
NSC 16276, 2-Pyridylphenylacetonitrile
α-Phenyl-α-(2-pyridyl)thioacetamide, also known as antigastrin and SC-15396, is an inhibitor of gastric acid secretion. -
GC45232
β-D-Glucosamine Pentaacetate
N-Acetyl-β-D-Glucosamine tetraacetate, NSC 224432
β-D-Glucosamine pentaacetate is an N-acetylglucosamine derivative that has been shown to promote hyaluronic acid production. -
GC49769
β-Glucogallin
1-O-Galloyl-β-D-glucose
A plant metabolite and an aldose reductase 2 inhibitor -
GC49890
β-Glycerophosphate-d5 (sodium salt hydrate)
Glycerol 2-Phosphate-d5
An internal standard for the quantification of β-glycerophosphate -
GC49647
β-Hyodeoxycholic Acid (hydrate)
3β,6α-dihydroxy-5β-Cholan-24-oic Acid, isoHDCA, Isohyodeoxycholic Acid
A 3β epimer of hyodeoxycholic acid -
GC49007
β-Muricholic Acid-d4
ω-MCA-d4
An internal standard for the quantification of β-muricholic acid -
GC41502
β-Myrcene
NSC 406264
β-Myrcene (β-ޚ-Myrcene), un compuesto volátil aromático, suprime la actividad de NF-κB inducida por TNFα. -
GC40551
γ-CEHC
γTocopherol Metabolite, GTM, 2,7,8trimethyl2(βCarboxyEthyl)6Hydroxychroman
The major tocopherol obtained from natural dietary sources is γ-tocopherol, whereas α-tocopherol is the form of Vitamin E typically obtained from synthetic supplements. -
GC52400
γ-Glu-Ala (trifluoroacetate salt)
γ-Glutamylalanine, γ-L-Glutamyl-L-alanine
A dipeptide -
GC52404
γ-Glu-Phe (trifluoroacetate salt)
γ-Glutamylphenylalanine
A dipeptide with metabolism-altering activity -
GC45239
δ4-Abiraterone
CB 7627, D4A
δ4-Abiraterona es un metabolito principal de abiraterona. δ4-Abiraterona es un inhibidor de CYP17A1, 3b-hidroxiesteroide deshidrogenasa (3βHSD) y esteroide-5a-reductasa (SRD5A) y también un antagonista del receptor de andrÓgenos. -
GC15975
α-Estradiol
Alfatradiol, α-Estradiol, 17-epi Estradiol, NSC 20293, 17α-Oestradiol
α-El estradiol es un estrÓgeno débil y un 5&7#945;-inhibidor de la reductasa que se usa como medicamento tÓpico en el tratamiento de la alopecia androgénica. -
GC49009
ω-Muricholic Acid-d4
ω-MCA-d4
An internal standard for the quantification of ω-MCA -
GC49296
τ-Fluvalinate
tau-Fluvalinate
A pyrethroid acaricide -
GC46314
(±)-β-Hydroxybutyrate-d4 (sodium salt)
βHydroxybutanoic Acidd4
An internal standard for the quantification of (±)βhydroxybutyrate -
GC52010
(±)-10-hydroxy-12(Z),15(Z)-Octadecadienoic Acid
αHYA, (±)-10-hydroxy-12(Z),15(Z)-ODE
An oxylipin gut microbiota metabolite -
GC52013
(±)-10-hydroxy-12(Z)-Octadecenoic Acid
10-hydroxy-cis-12-Octadecenoic Acid
An oxylipin and metabolite of linoleic acid -
GC52421
(±)-10-hydroxy-12(Z)-Octadecenoic Acid-d5
10-hydroxy-cis-12-Octadecenoic Acid-d5
An internal standard for the quantification of (±)-10-hydroxy-12(Z)-octadecenoic acid - GC41661 (±)-4-hydroxy Propranolol β-D-Glucuronide (±)-4-hydroxy Propranolol β-D-glucuronide is a metabolite of (±)-4-hydroxy propranolol, which is a metabolite of propranolol.
- GC46284 (±)-Cotinine-d3 An internal standard for the quantification of cotinine
-
GC41671
(±)-Equol 4'-sulfate (sodium salt)
R,S-Equol 4'-Sulfate
(±)-Equol 4'-sulfate is a gut-mediated phase II metabolite of the isoflavonoid phytoestrogen (±)-equol.
-
GC41315
(±)-Ketoprofen Glucuronide
rac-Ketoprofen Acyl-β-D-glucuronide, (R,S)-Ketoprofen Glucuronide
(±)-Ketoprofen glucuronide is a phase II metabolite of the non-steroidal anti-inflammatory drug (NSAID) ketoprofen. -
GC40954
(±)-N-3-Benzylnirvanol
(S)-N-3-benzyl Nirvanol
(±)-N-3-Benzylnirvanol is a racemic mixture of (+)-N-3-benzylnirvanol and (-)-N-3-benzylnirvanol. -
GC49875
(±)-N-desmethyl Venlafaxine (hydrochloride)
Wy 45494
A minor active metabolite of venlafaxine -
GC39271
(±)-Naringenin
SDihydrogenistein, NSC 11855, NSC 34875, Salipurol
(±)-naringenina es un flavonoide natural. -
GC45618
(±)-trans-GK563
GK563
A GVIA iPLA2 inhibitor -
GC40802
(±)12(13)-DiHOME
Isoleukotoxin diol
(±)12(13)-DiHOME is the diol form of (±)12(13)-EpOME, a cytochrome P450-derived epoxide of linoleic acid also known as isoleukotoxin.
-
GC40270
(±)5(6)-DiHET
(±)5,6-DiHETrE
5(6)-DiHET is a fully racemic version of the enantiomeric forms biosynthesized from 5(6)-EET by epoxide hydrolases.
-
GC40282
(+)-5-trans Cloprostenol
DCloprostenol, (+)5,6trans Cloprostenol, (+)5trans16mchlorophenoxy tetranor PGF2α, (+)5trans16mchlorophenoxy tetranor Prostaglandin F2α
Cloprostenol is a synthetic derivative of prostaglandin F2α that is used in veterinary medicine as a luteolytic agent for the induction of estrus and in the treatment of reproductive disorders in cattle, swine, and horses. -
GC45260
(+)-Cloprostenol isopropyl ester
(+)-5-cis Cloprostenol isopropyl ester, (+)16mchlorophenoxy tetranor Prostaglandin F2α isopropyl ester
(+) - éster isopropÍlico de cloprostenol, una prostaglandina F2α anÁlogos, es el intermedio de (+)-cloprostenol. -
GC45262
(+)-Cloprostenol methyl ester
DCloprostenol methyl ester, (+)16mChlorophenoxy tetranor PGF2α methyl ester
(+)-Cloprostenol is a synthetic analog of prostaglandin F2α (PGF2α). - GC45264 (+)-Geodin (+) - Geodin, un metabolito fúngico, muestra actividad antibacteriana.
-
GC12404
(+)-Ketoconazole
R 41400
(+)-ketoconazol ((+)-R 41400) es un agente antifÚngico de imidazol, un inhibidor de CYP3A4. - GC30424 (-)-Cephaeline dihydrochloride (NSC 32944) El diclorhidrato de (-)-cefaelina (NSC 32944) es un inhibidor selectivo de CYP2D6 con un IC50 de 121 μM.
- GC18343 (-)-CP 55,940 (-)-CP 55,940 is a potent and non-selective cannabinoid (CB) receptor agonist with Ki values of 0.5 to 5 and 0.69 to 2.8 nM for CB1 and CB2 receptors, respectively.
-
GC14049
(-)-Epigallocatechin gallate (EGCG)
EGCG
Un fenol con diversas actividades biológicas.
- GC45248 (-)-FINO2 (-)-FINO2 es un potente inductor de ferroptosis. (-)-FINO2 inhibe la actividad de GPX4. (-)-FINO2 es un oxidante estable que oxida el hierro ferroso y es estable a diferentes niveles de pH. (-)-FINO2 provoca una peroxidaciÓn lipÍdica generalizada.
-
GC14520
(-)-p-Bromotetramisole Oxalate
(-)-p-Bromotetramisole, L-para-Bromotetramisole
Inhibidor de la ALP, potente y no específico.
-
GC45252
(-)-Sitagliptin Carbamoyl Glucuronide
(R)-Sitagliptin Carbamoyl Glucuronide
(-)-Sitagliptin carbamoyl glucuronide is a minor phase II metabolite of the dipeptidyl peptidase 4 (DPP-4) inhibitor (-)-sitagliptin. -
GC18622
(2'S)-Nicotine-1-oxide
Nicotine-N-oxide
(2'S)-Nicotine-1-oxide is a metabolite of nicotine . -
GC41691
(2R)-Glycerol-O-β-D-galactopyranoside
3-O-β-D-Galactopyranosyl-sn-glycerol
(2R)-Glicerol-O-β-D-galactopiranÓsido (3-O-β-D-Galactopiranosil-sn-glicerol) es un buen sustrato para los tres componentes del operÓn lac, i. - GC49690 (3R,5R)-Rosuvastatin (calcium salt) A potential impurity found in bulk preparations of rosuvastatin
- GC41694 (3S)-hydroxy Quinidine (3S)-hydroxy Quinidine is an active quinidine metabolite.
- GC60396 (3S,5R)-Fluvastatin sodium (3S,5R)-fluvastatina sÓdica ((3S,5R)-XU 62-320) es el enantiÓmero (3S,5R)de fluvastatina.
-
GC68317
(3S,5R)-Fluvastatin-d6 sodium
(3S,5R)-XU 62-320 D6
- GC13751 (3S,5S)-Atorvastatin (sodium salt) negetive control of Atorvastatin, HMG-CoA reductase inhibitor
- GC46333 (4′-Hydroxy)phenoxybenzoic Acid A pyrethroid insecticide metabolite
-
GC48508
(4-Carboxybutyl-d4)triphenylphosphonium (bromide)
TPP-d4, 5-Triphenylphosphoniovaleric Acid-d4
An internal standard for the quantification of (4-carboxybutyl)triphenylphosphonium -
GC41695
(6R,S)-5,6,7,8-Tetrahydrofolic Acid (hydrochloride)
Tetrahydrofolate, THFA
(6R,S)-5,6,7,8-Tetrahydrofolic acid (THFA), the reduced form of folic acid, serves as a cofactor in methyltransferase reactions and is the major one-carbon carrier in one carbon metabolism. - GC41088 (6S)-Tetrahydrofolic Acid (6S)-Tetrahydrofolic acid is a diastereomer of tetrahydrofolic acid, a reduced form of folic acid that serves as a cofactor in methyltransferase reactions and is the major one-carbon carrier in one carbon metabolism.
- GC34980 (E)-Ferulic acid El Ácido (E)-ferÚlico es un isÓmero del Ácido ferÚlico, que es un compuesto aromÁtico, abundante en las paredes celulares de las plantas. El Ácido (E)-ferÚlico provoca la fosforilaciÓn de la β-catenina, lo que da como resultado la degradaciÓn proteasomal de la β-catenina y aumenta la expresiÓn del factor proapoptÓtico Bax y disminuye la expresiÓn del factor prosupervivencia survivina. El Ácido (E)-ferÚlico muestra una potente capacidad para eliminar las especies reactivas de oxÍgeno (ROS) e inhibe la peroxidaciÓn lipÍdica. El Ácido (E)-ferÚlico ejerce efectos antiproliferaciÓn y antimigraciÓn en la lÍnea celular de cÁncer de pulmÓn humano H1299.
-
GC40286
(E,Z)-2-propyl-2-Pentenoic Acid
2-propyl-2-Pentenoate, 2-propylpenten-2-oic Acid, 2-ene-VPA
(E,Z)-2-propyl-2-Pentenoic acid is a bioactive metabolite of valproic acid that exhibits the same profile and potency of anticonvulsant activity in animal models as its parent compound without any observed teratogenicity and hepatotoxicity. -
GC49189
(E/Z)-4-hydroxy Tamoxifen-d5
Afimoxifene-d5, 4-OHT-d5
An internal standard for the quantification of (E/Z)-4-hydroxy tamoxifen -
GA11210
(H-Cys-OH)2
(–)-Cystine, NSC 13203
-
GC34984
(R)-(-)-Rolipram
(R)-(–)-Rolipram, (R)-Rolipram
(R)-(-)-Rolipram es el enantiÓmero R de Rolipram. - GC25001 (R)-Avanafil R-Avanafil is a strong competitive inhibitor of phosphodiesterase 5 (PDE5) with a demonstrated in vitro IC 50 of 5.2 nM.
-
GC40678
(R)-Bromoenol lactone
(R)BEL
La (R)-bromoenol lactona ((R)-BEL) es un inhibidor irreversible, quiral y basado en un mecanismo de la fosfolipasa γ independiente del calcio (iPLA2γ). - GC52290 (R)-HTS-3 An inhibitor of LPCAT3
-
GC67864
(R)-Irsenontrine
(R)-E2027
- GC41722 (R,S)-Carvedilol Glucuronide (R,S)-Carvedilol glucuronide is a racemic mixture of the carvedilol metabolites (R)-carvedilol glucuronide and (S)-carvedilol glucuronide.
- GC61548 (Rac)-5-Keto Fluvastatin (Rac)-5-Keto Fluvastatin (3-Hydroxy-5-Keto Fluvastatin) es una impureza de Fluvastatin (XU 62320).
-
GC62743
(Rac)-EC5026
(Rac)-BPN-19186
(Rac)-EC5026 ((Rac)-BPN-19186) es un potente inhibidor de piperidina de la epÓxido hidrolasa soluble (sEH) extraÍdo de la patente WO2019156991A1, pÁgina 39, tiene una Ki de 0,06 nM. -
GC69796
(Rac)-Etavopivat
(Rac)-FT-4202
(Rac)-Etavopivat ((Rac)-FT-4202) es un isómero de Etavopivat. Etavopivat es un activador oralmente activo de la piruvato quinasa-R (PKR) en los glóbulos rojos, que se puede utilizar para investigar la enfermedad de células falciformes y otras enfermedades de hemoglobina.
- GC61750 (Rac)-Indoximod (Rac)-indoximod (1-metil-DL-triptÓfano) es un inhibidor de la indolamina 2,3-dioxigenasa (IDO).
-
GC46347
(S)-(+)-Methoprene
Altosid, d-Methoprene, ZR 2458
El (S)-metopreno es un análogo de la hormona juvenil que impide que el insecto cambie de pupa a adulto y se usa como insecticida. -
GC40679
(S)-Bromoenol lactone
(S)BEL
La (S)-bromoenol lactona ((S)-BEL) es un inhibidor irreversible, quiral, basado en un mecanismo de la fosfolipasa A2β independiente del calcio (iPLA2β) que inhibe la liberaciÓn de araquidonato inducida por vasopresina a partir de mÚsculo liso aÓrtico de rata en cultivo (A10) células con una IC50 de 2 μM. - GC50321 (S)-C33 (S)-C33 es un inhibidor potente y selectivo de la PDE9 (fosfodiesterasa-9), con una IC50 de 11 nM.
-
GC48719
(S)-Canadine
(–)-Canadine, (S)-Tetrahydroberberine
La (S)-canadina es un alcaloide e intermedio en la biosÍntesis de la berberina con actividad insecticida. - GC46352 (S)-DO271 An inactive control for DO264
-
GC49520
(S)-Equol
4',7Dihydroxyisoflavan, (-)Equol, 4',7Isoflavandiol
Un agonista del receptor de estrógeno β.
-
GC60417
(S)-Indoximod
NSC 77678, L-1-Methyltryptophan, 1-L-MT, L-1MT
El (S)-indoximod (1-metil-L-triptÓfano) es un inhibidor de la indolamina 2,3-dioxigenasa (IDO). (S)-Indoximod se puede utilizar para la investigaciÓn del cÁncer. -
GC69891
(S)-Indoximod-d3
1-Methyl-L-tryptophan-d3; (S)-NLG-8189-d3
(S)-Indoximod-d3 es la forma deuterada de (S)-Indoximod. (S)-Indoximod (1-Metil-L-triptófano) es un inhibidor de la enzima indolamina-2,3-dioxigenasa (IDO). (S)-Indoximod se utiliza en investigaciones sobre el cáncer.
-
GC40145
(S)-Laudanosine
(+)-Laudanosine, L-Laudanosine, L-(+)-Laudanosine, NSC 35045
(S)-Laudanosine is the (S) enantiomer of laudanosine, a metabolite of the neuromuscular blocking agents atracurium and cisatracurium. -
GC14486
(S)-Mephenytoin
(S)-5-Ethyl-3-methyl-5-phenylhydantoin
(S)-Mephenytoin ((+)-Mephenytoin) es un agente anticonvulsivo. -
GC49179
(S)-O-Desmethyl Naproxen
(S)-6-Desmethyl Naproxen
A metabolite of (S)-naproxen -
GC18596
(±)-2-propyl-4-Pentenoic Acid
2-Allylpentanoic Acid, 4-ene VPA
El Ácido (±)-2-propil-4-pentenoico (4-en-VPA) es un metabolito tÓxico principal del Ácido valproico. - GC49034 1(R)-(Trifluoromethyl)oleyl alcohol An oleic acid analog
-
GC46365
1,1'-(Azodicarbonyl)dipiperidine
ADDP, NSC 356027
A Mitsunobu reagent - GC41762 1,2,3,5-Tetra-O-acetyl-D-xylofuranose 1,2,3,5-Tetra-O-acetil-D-xilofuranosa es la materia prima para la sÍntesis de nucleÓtidos.
-
GC46040
1,2,3-Trielaidoyl-rac-glycerol
Glycerol Trielaidate, TG(18:1(9E)/18:1(9E)/18:1(9E)), Trielaidin
A triacylglycerol -
GC45698
1,2,3-Triheptanoyl-rac-glycerol
Glycerol Triheptanoate, TG(7:0/7:0/7:0), Triheptanoin
El 1,2,3-triheptanoil-rac-glicerol (propano-1,2,3-triiltriheptanoato) es un triglicérido de cadena media (MCT) sintético que consta de tres Ácidos grasos de cadena impar de 7 carbonos (heptanoato) en un glicerol columna vertebral. -
GC45285
1,2,3-Trihexanoyl-rac-glycerol
Glycerol trihexanoate, NSC 406885, Tricaproin, Trihexanoin
-
GC45956
1,2,3-Trinonanoyl-rac-glycerol
Glyceryl Trinonanoate, NSC 5647, Trinonanoin, Tripelargonin
A triacylglycerol -
GC46009
1,2,3-Trioctanoyl-rac-glycerol-13C3
Glycerol Trioctanoate-13C3, TG(8:0/8:0/8:0)-13C3, Trioctanoin-13C3
An internal standard for the quantification of 1,2,3-trioctanoyl glycerol-13C3 -
GC46373
1,2,3-Triundecanoyl Glycerol
Glycerol Triundecanoate, TG(11:0/11:0/11:0), Triundecanoin, Triundecanoyl Glycerol
A triacylglycerol -
GC41782
1,2-bis(heptanoylthio) Glycerophosphocholine
Diheptanoyl ThioPC, 1,2bis(Heptanoylthio)1,2dideoxysnglycero3phosphorylcholine
Diheptanoyl Thio-PC is a substrate for all phospholipase A2s (PLA2s) with the exception of cPLA2 and PAF-acetyl hydrolase (PAF-AH). -
GC40236
1,2-Dilinoleoyl-sn-glycerol
1,2-Dioleoyl-sn-glycerol
1,2-Dilinoleoyl-sn-glycerol is a diacylglycerol (DAG) with linoleic acid (18:2) side chains attached at both the sn-1 and sn-2 positions. -
GC41808
1,2-Dioctanoyl PC
1,2-bis(O-octanoyl)-sn-glyceryl-Phophorylcholine, 1,2-DCPC, 1,2-Dicapryloyl-sn-glycero-3-PC, 1,2-Dioctanoyl Phosphatidylcholine
Phosphatidylcholine (PC) species are a common class of phospholipids that comprise the mammalian cell membrane.
-
GC41837
1,3,7-Trimethyluric Acid
8-oxo Caffeine, NSC 11259
El Ácido 1,3,7-trimetilÚrico es el metabolito de la cafeÍna. La proporciÓn metabÓlica de Ácido 1,3,7-trimetilÚrico a cafeÍna se puede evaluar como biomarcador para describir la variabilidad en la actividad de CYP3A en una cohorte.