Metabolism
- Sterol Biosynthesis(26)
- PPAR(183)
- 5-alpha Reductase(9)
- 5-Lipoxygenase(11)
- Adenosine Deaminase(6)
- Aminopeptidase(7)
- C14ɑ demethylase(2)
- Carbonic Anhydrase(56)
- CETP(9)
- Cholesterol absorption(1)
- CPT1(2)
- CYP3A/CYP450(22)
- Dehydrogenase(132)
- DHFR(6)
- DGAT(8)
- Dopamine β-hydroxylase(10)
- Enolase(11)
- FAAH(34)
- Factor Xa(41)
- Ferroptosis(159)
- Folate Analogue(2)
- Glucokinase(17)
- HLE(0)
- HMG-CoA Reductase(34)
- HSP(59)
- IDO(45)
- KRAS-PDEδ(3)
- MAO(6)
- Metabolic Enzymes(0)
- Neuronal Metabolism(8)
- Oxidative Phosphorylation(17)
- P450(120)
- PDE(223)
- Phospholipase(113)
- Procollagen C Proteinase(1)
- Saccharometabolism(1)
- SCD(16)
- SGLT(26)
- TPH(4)
- Transferase(177)
- Energy Metabolism(0)
- Inorganic Ions(0)
- ALP(1)
- Carbohydrates(18)
- Uric Acid(0)
- Muscle Metabolism(0)
- MDA(0)
- MPO(0)
- Transaminase(20)
- Glutathione Reductase(0)
- Thioredoxin Reductase(0)
- Catalase(8)
- monooxygenase(1)
- PKM2(1)
- aldehyde dehydrogenase(1)
- Squalene synthase(1)
- Hydrolase(47)
- ornithine decarboxylase(1)
- Amino acid metabolism(3)
- phosphatases(92)
- Pyruvate kinase(8)
- Others(4)
- MGL(1)
- Galactosidase(6)
- 12-Lipoxygenase(1)
- Fatty Acid Synthase (FASN)(9)
- Dihydroorotate Dehydrogenase(12)
- Bile Acids & Microbiome(94)
- Bone Growth & Remodeling(35)
- Carbohydrate Metabolism(126)
- Cofactors & Vitamins(64)
- Dyslipidemias(73)
- Inborn Errors of Metabolism(80)
- Metabolic Syndrome(16)
- Necroptosis(10)
- Necrosis(15)
- Nutrient Sensing(12)
- Phosphodiesterase(27)
- Reproductive Biology(126)
- Thermogenesis(6)
- Prolyl Hydroxylation Enzymes(1)
- Biliary System(4)
- Metabolic Disease(4)
- Fat Mass and Obesity-associated Protein (FTO)(2)
- SHIP(1)
Products for Metabolism
- Cat.No. Nombre del producto Información
- GC66197 α-?Terpinyl acetate α-El acetato de terpinilo es un éster de monoterpeno aislado del aceite esencial de Laurus nobilis L. α-El acetato de terpinilo es un sustrato competitivo de P450 2B6 que se une al sitio activo de P450 2B6 con un valor Kd de 5,4μM.
- GC11123 α-CEHC A major metabolite of δ-tocopherol
- GC48276 α-Cyclodextrin (hydrate) A cyclic hexasaccharide
- GC48278 α-D-Glucose-1,6-bisphosphate (potassium salt hydrate) A bis-phosphorylated derivative of α-D-glucose
- GC48279 α-D-Glucose-1-phosphate (sodium salt hydrate) An intermediate in glycogen metabolism
- GC52253 α-Enolase (1-19)-biotin Peptide A biotinylated α-enolase peptide
- GC45208 α-hydroxy Metoprolol α-hydroxy Metoprolol is an active metabolite of the β1-adrenergic receptor blocker metoprolol.
- GC45210 α-Linolenic Acid (sodium salt) α-Linolenic acid (ALA) is an essential fatty acid found in leafy green vegetables.
- GC48283 α-Linolenic Acid-d14 An internal standard for the quantification of αLinolenic acid
- GC45602 α-Linolenic Acid-d5 MaxSpec• Standard
- GC49008 α-Muricholic Acid-d4 An internal standard for the quantification of α-muricholic acid
- GC40480 α-Phenyl-α-(2-pyridyl)acetonitrile α-Phenyl-α-(2-pyridyl)thioacetamide, also known as antigastrin and SC-15396, is an inhibitor of gastric acid secretion.
- GC45232 β-D-Glucosamine Pentaacetate β-D-Glucosamine pentaacetate is an N-acetylglucosamine derivative that has been shown to promote hyaluronic acid production.
- GC49769 β-Glucogallin A plant metabolite and an aldose reductase 2 inhibitor
- GC49890 β-Glycerophosphate-d5 (sodium salt hydrate) An internal standard for the quantification of β-glycerophosphate
- GC49647 β-Hyodeoxycholic Acid (hydrate) A 3β epimer of hyodeoxycholic acid
- GC49007 β-Muricholic Acid-d4 An internal standard for the quantification of β-muricholic acid
- GC41502 β-Myrcene β-Myrcene (β-ޚ-Myrcene), un compuesto volátil aromático, suprime la actividad de NF-κB inducida por TNFα.
- GC40551 γ-CEHC The major tocopherol obtained from natural dietary sources is γ-tocopherol, whereas α-tocopherol is the form of Vitamin E typically obtained from synthetic supplements.
- GC52400 γ-Glu-Ala (trifluoroacetate salt) A dipeptide
- GC52404 γ-Glu-Phe (trifluoroacetate salt) A dipeptide with metabolism-altering activity
- GC45239 δ4-Abiraterone δ4-Abiraterona es un metabolito principal de abiraterona. δ4-Abiraterona es un inhibidor de CYP17A1, 3b-hidroxiesteroide deshidrogenasa (3βHSD) y esteroide-5a-reductasa (SRD5A) y también un antagonista del receptor de andrÓgenos.
- GC15975 α-Estradiol α-El estradiol es un estrÓgeno débil y un 5&7#945;-inhibidor de la reductasa que se usa como medicamento tÓpico en el tratamiento de la alopecia androgénica.
- GC49009 ω-Muricholic Acid-d4 An internal standard for the quantification of ω-MCA
- GC49296 τ-Fluvalinate A pyrethroid acaricide
- GC46314 (±)-β-Hydroxybutyrate-d4 (sodium salt) An internal standard for the quantification of (±)βhydroxybutyrate
- GC52010 (±)-10-hydroxy-12(Z),15(Z)-Octadecadienoic Acid An oxylipin gut microbiota metabolite
- GC52013 (±)-10-hydroxy-12(Z)-Octadecenoic Acid An oxylipin and metabolite of linoleic acid
- GC52421 (±)-10-hydroxy-12(Z)-Octadecenoic Acid-d5 An internal standard for the quantification of (±)-10-hydroxy-12(Z)-octadecenoic acid
- GC41661 (±)-4-hydroxy Propranolol β-D-Glucuronide (±)-4-hydroxy Propranolol β-D-glucuronide is a metabolite of (±)-4-hydroxy propranolol, which is a metabolite of propranolol.
- GC46284 (±)-Cotinine-d3 An internal standard for the quantification of cotinine
-
GC41671
(±)-Equol 4'-sulfate (sodium salt)
(±)-Equol 4'-sulfate is a gut-mediated phase II metabolite of the isoflavonoid phytoestrogen (±)-equol.
- GC41315 (±)-Ketoprofen Glucuronide (±)-Ketoprofen glucuronide is a phase II metabolite of the non-steroidal anti-inflammatory drug (NSAID) ketoprofen.
- GC40954 (±)-N-3-Benzylnirvanol (±)-N-3-Benzylnirvanol is a racemic mixture of (+)-N-3-benzylnirvanol and (-)-N-3-benzylnirvanol.
- GC49875 (±)-N-desmethyl Venlafaxine (hydrochloride) A minor active metabolite of venlafaxine
- GC39271 (±)-Naringenin (±)-naringenina es un flavonoide natural.
- GC45618 (±)-trans-GK563 A GVIA iPLA2 inhibitor
-
GC40802
(±)12(13)-DiHOME
(±)12(13)-DiHOME is the diol form of (±)12(13)-EpOME, a cytochrome P450-derived epoxide of linoleic acid also known as isoleukotoxin.
-
GC40270
(±)5(6)-DiHET
5(6)-DiHET is a fully racemic version of the enantiomeric forms biosynthesized from 5(6)-EET by epoxide hydrolases.
- GC40282 (+)-5-trans Cloprostenol Cloprostenol is a synthetic derivative of prostaglandin F2α that is used in veterinary medicine as a luteolytic agent for the induction of estrus and in the treatment of reproductive disorders in cattle, swine, and horses.
- GC45260 (+)-Cloprostenol isopropyl ester (+) - éster isopropÍlico de cloprostenol, una prostaglandina F2α anÁlogos, es el intermedio de (+)-cloprostenol.
- GC45262 (+)-Cloprostenol methyl ester (+)-Cloprostenol is a synthetic analog of prostaglandin F2α (PGF2α).
- GC45264 (+)-Geodin (+) - Geodin, un metabolito fúngico, muestra actividad antibacteriana.
- GC12404 (+)-Ketoconazole (+)-ketoconazol ((+)-R 41400) es un agente antifÚngico de imidazol, un inhibidor de CYP3A4.
- GC30424 (-)-Cephaeline dihydrochloride (NSC 32944) El diclorhidrato de (-)-cefaelina (NSC 32944) es un inhibidor selectivo de CYP2D6 con un IC50 de 121 μM.
- GC18343 (-)-CP 55,940 (-)-CP 55,940 is a potent and non-selective cannabinoid (CB) receptor agonist with Ki values of 0.5 to 5 and 0.69 to 2.8 nM for CB1 and CB2 receptors, respectively.
-
GC14049
(-)-Epigallocatechin gallate (EGCG)
Un fenol con diversas actividades biológicas.
- GC45248 (-)-FINO2 (-)-FINO2 es un potente inductor de ferroptosis. (-)-FINO2 inhibe la actividad de GPX4. (-)-FINO2 es un oxidante estable que oxida el hierro ferroso y es estable a diferentes niveles de pH. (-)-FINO2 provoca una peroxidaciÓn lipÍdica generalizada.
-
GC14520
(-)-p-Bromotetramisole Oxalate
Inhibidor de la ALP, potente y no específico.
- GC45252 (-)-Sitagliptin Carbamoyl Glucuronide (-)-Sitagliptin carbamoyl glucuronide is a minor phase II metabolite of the dipeptidyl peptidase 4 (DPP-4) inhibitor (-)-sitagliptin.
- GC18622 (2'S)-Nicotine-1-oxide (2'S)-Nicotine-1-oxide is a metabolite of nicotine .
- GC41691 (2R)-Glycerol-O-β-D-galactopyranoside (2R)-Glicerol-O-β-D-galactopiranÓsido (3-O-β-D-Galactopiranosil-sn-glicerol) es un buen sustrato para los tres componentes del operÓn lac, i.
- GC49690 (3R,5R)-Rosuvastatin (calcium salt) A potential impurity found in bulk preparations of rosuvastatin
- GC41694 (3S)-hydroxy Quinidine (3S)-hydroxy Quinidine is an active quinidine metabolite.
- GC60396 (3S,5R)-Fluvastatin sodium (3S,5R)-fluvastatina sÓdica ((3S,5R)-XU 62-320) es el enantiÓmero (3S,5R)de fluvastatina.
- GC68317 (3S,5R)-Fluvastatin-d6 sodium
- GC13751 (3S,5S)-Atorvastatin (sodium salt) negetive control of Atorvastatin, HMG-CoA reductase inhibitor
- GC46333 (4′-Hydroxy)phenoxybenzoic Acid A pyrethroid insecticide metabolite
- GC48508 (4-Carboxybutyl-d4)triphenylphosphonium (bromide) An internal standard for the quantification of (4-carboxybutyl)triphenylphosphonium
- GC41695 (6R,S)-5,6,7,8-Tetrahydrofolic Acid (hydrochloride) (6R,S)-5,6,7,8-Tetrahydrofolic acid (THFA), the reduced form of folic acid, serves as a cofactor in methyltransferase reactions and is the major one-carbon carrier in one carbon metabolism.
- GC41088 (6S)-Tetrahydrofolic Acid (6S)-Tetrahydrofolic acid is a diastereomer of tetrahydrofolic acid, a reduced form of folic acid that serves as a cofactor in methyltransferase reactions and is the major one-carbon carrier in one carbon metabolism.
- GC34980 (E)-Ferulic acid El Ácido (E)-ferÚlico es un isÓmero del Ácido ferÚlico, que es un compuesto aromÁtico, abundante en las paredes celulares de las plantas. El Ácido (E)-ferÚlico provoca la fosforilaciÓn de la β-catenina, lo que da como resultado la degradaciÓn proteasomal de la β-catenina y aumenta la expresiÓn del factor proapoptÓtico Bax y disminuye la expresiÓn del factor prosupervivencia survivina. El Ácido (E)-ferÚlico muestra una potente capacidad para eliminar las especies reactivas de oxÍgeno (ROS) e inhibe la peroxidaciÓn lipÍdica. El Ácido (E)-ferÚlico ejerce efectos antiproliferaciÓn y antimigraciÓn en la lÍnea celular de cÁncer de pulmÓn humano H1299.
- GC40286 (E,Z)-2-propyl-2-Pentenoic Acid (E,Z)-2-propyl-2-Pentenoic acid is a bioactive metabolite of valproic acid that exhibits the same profile and potency of anticonvulsant activity in animal models as its parent compound without any observed teratogenicity and hepatotoxicity.
- GC49189 (E/Z)-4-hydroxy Tamoxifen-d5 An internal standard for the quantification of (E/Z)-4-hydroxy tamoxifen
- GA11210 (H-Cys-OH)2
- GC34984 (R)-(-)-Rolipram (R)-(-)-Rolipram es el enantiÓmero R de Rolipram.
- GC25001 (R)-Avanafil R-Avanafil is a strong competitive inhibitor of phosphodiesterase 5 (PDE5) with a demonstrated in vitro IC 50 of 5.2 nM.
- GC40678 (R)-Bromoenol lactone La (R)-bromoenol lactona ((R)-BEL) es un inhibidor irreversible, quiral y basado en un mecanismo de la fosfolipasa γ independiente del calcio (iPLA2γ).
- GC52290 (R)-HTS-3 An inhibitor of LPCAT3
- GC67864 (R)-Irsenontrine
- GC41722 (R,S)-Carvedilol Glucuronide (R,S)-Carvedilol glucuronide is a racemic mixture of the carvedilol metabolites (R)-carvedilol glucuronide and (S)-carvedilol glucuronide.
- GC61548 (Rac)-5-Keto Fluvastatin (Rac)-5-Keto Fluvastatin (3-Hydroxy-5-Keto Fluvastatin) es una impureza de Fluvastatin (XU 62320).
- GC62743 (Rac)-EC5026 (Rac)-EC5026 ((Rac)-BPN-19186) es un potente inhibidor de piperidina de la epÓxido hidrolasa soluble (sEH) extraÍdo de la patente WO2019156991A1, pÁgina 39, tiene una Ki de 0,06 nM.
-
GC69796
(Rac)-Etavopivat
(Rac)-Etavopivat ((Rac)-FT-4202) es un isómero de Etavopivat. Etavopivat es un activador oralmente activo de la piruvato quinasa-R (PKR) en los glóbulos rojos, que se puede utilizar para investigar la enfermedad de células falciformes y otras enfermedades de hemoglobina.
- GC61750 (Rac)-Indoximod (Rac)-indoximod (1-metil-DL-triptÓfano) es un inhibidor de la indolamina 2,3-dioxigenasa (IDO).
- GC46347 (S)-(+)-Methoprene El (S)-metopreno es un análogo de la hormona juvenil que impide que el insecto cambie de pupa a adulto y se usa como insecticida.
- GC40679 (S)-Bromoenol lactone La (S)-bromoenol lactona ((S)-BEL) es un inhibidor irreversible, quiral, basado en un mecanismo de la fosfolipasa A2β independiente del calcio (iPLA2β) que inhibe la liberaciÓn de araquidonato inducida por vasopresina a partir de mÚsculo liso aÓrtico de rata en cultivo (A10) células con una IC50 de 2 μM.
- GC50321 (S)-C33 (S)-C33 es un inhibidor potente y selectivo de la PDE9 (fosfodiesterasa-9), con una IC50 de 11 nM.
- GC48719 (S)-Canadine La (S)-canadina es un alcaloide e intermedio en la biosÍntesis de la berberina con actividad insecticida.
- GC46352 (S)-DO271 An inactive control for DO264
-
GC49520
(S)-Equol
Un agonista del receptor de estrógeno β.
- GC60417 (S)-Indoximod El (S)-indoximod (1-metil-L-triptÓfano) es un inhibidor de la indolamina 2,3-dioxigenasa (IDO). (S)-Indoximod se puede utilizar para la investigaciÓn del cÁncer.
-
GC69891
(S)-Indoximod-d3
(S)-Indoximod-d3 es la forma deuterada de (S)-Indoximod. (S)-Indoximod (1-Metil-L-triptófano) es un inhibidor de la enzima indolamina-2,3-dioxigenasa (IDO). (S)-Indoximod se utiliza en investigaciones sobre el cáncer.
- GC40145 (S)-Laudanosine (S)-Laudanosine is the (S) enantiomer of laudanosine, a metabolite of the neuromuscular blocking agents atracurium and cisatracurium.
- GC14486 (S)-Mephenytoin (S)-Mephenytoin ((+)-Mephenytoin) es un agente anticonvulsivo.
- GC49179 (S)-O-Desmethyl Naproxen A metabolite of (S)-naproxen
- GC18596 (±)-2-propyl-4-Pentenoic Acid El Ácido (±)-2-propil-4-pentenoico (4-en-VPA) es un metabolito tÓxico principal del Ácido valproico.
- GC49034 1(R)-(Trifluoromethyl)oleyl alcohol An oleic acid analog
- GC46365 1,1'-(Azodicarbonyl)dipiperidine A Mitsunobu reagent
- GC41762 1,2,3,5-Tetra-O-acetyl-D-xylofuranose 1,2,3,5-Tetra-O-acetil-D-xilofuranosa es la materia prima para la sÍntesis de nucleÓtidos.
- GC46040 1,2,3-Trielaidoyl-rac-glycerol A triacylglycerol
- GC45698 1,2,3-Triheptanoyl-rac-glycerol El 1,2,3-triheptanoil-rac-glicerol (propano-1,2,3-triiltriheptanoato) es un triglicérido de cadena media (MCT) sintético que consta de tres Ácidos grasos de cadena impar de 7 carbonos (heptanoato) en un glicerol columna vertebral.
- GC45285 1,2,3-Trihexanoyl-rac-glycerol
- GC45956 1,2,3-Trinonanoyl-rac-glycerol A triacylglycerol
- GC46009 1,2,3-Trioctanoyl-rac-glycerol-13C3 An internal standard for the quantification of 1,2,3-trioctanoyl glycerol-13C3
- GC46373 1,2,3-Triundecanoyl Glycerol A triacylglycerol
- GC41782 1,2-bis(heptanoylthio) Glycerophosphocholine Diheptanoyl Thio-PC is a substrate for all phospholipase A2s (PLA2s) with the exception of cPLA2 and PAF-acetyl hydrolase (PAF-AH).
- GC40236 1,2-Dilinoleoyl-sn-glycerol 1,2-Dilinoleoyl-sn-glycerol is a diacylglycerol (DAG) with linoleic acid (18:2) side chains attached at both the sn-1 and sn-2 positions.
-
GC41808
1,2-Dioctanoyl PC
Phosphatidylcholine (PC) species are a common class of phospholipids that comprise the mammalian cell membrane.
- GC41837 1,3,7-Trimethyluric Acid El Ácido 1,3,7-trimetilÚrico es el metabolito de la cafeÍna. La proporciÓn metabÓlica de Ácido 1,3,7-trimetilÚrico a cafeÍna se puede evaluar como biomarcador para describir la variabilidad en la actividad de CYP3A en una cohorte.