2'-Deoxy-L-adenosine |
Katalog-Nr.GC67328 |
2'-Desoxy-L-adenosin ist ein oral aktives Synthon für modifizierte Oligodesoxyribonukleotide. 2'-Desoxy-L-adenosin ist ein potenter, spezifischer und selektiver Inhibitor der Replikation des Hepatitis-B-Virus (HBV) sowie der eng verwandten Enten- und Waldmurmeltier-Hepatitisviren (WHV).
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Cas No.: 14365-45-8
Sample solution is provided at 25 µL, 10mM.
2'-Deoxy-L-adenosine is an orally active synthon for modified oligodeoxyribonucleotides. 2'-Deoxy-L-adenosine is a potent, specific and selective inhibitor of the replication of hepatitis B virus (HBV) as well as the closely related duck and woodchuck hepatitis viruses (WHV)[1].
2'-Deoxy-L-adenosine shows anti-hepadnavirus activity, withour affecting the replication of 15 other RNA and DNA viruses, neither nor inhibiting human DNA polymerases (α, β, and γ) or compromise mitochondrial function[1].
2'-Deoxy-L-adenosine (p.o.; once daily) reduces viral load by as much as 108 genome equivalent/mL serum without drug-related toxicity in woodchuck efficacy model of chronic HBV infection[1].
[1]. Standring DN, et al. Antiviral beta-L-nucleosides specific for hepatitis B virus infection. Antivir Chem Chemother. 2001;12 Suppl 1:119-29.
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