25-Hydroxycholesterol (Synonyms: 25-OH Cholesterol) |
| Katalog-Nr.GC33860 |
25-Hydroxycholesterol ist ein Metabolit von Cholesterin, der von Makrophagen als Reaktion auf die Aktivierung des Toll-like-Rezeptors (TLR) produziert und ausgeschieden wird.
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Cas No.: 2140-46-7
Sample solution is provided at 25 µL, 10mM.
25-Hydroxycholesterol is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells.
The synthesis of 25-hydroxycholesterol is catalyzed by the enzyme cholesterol 25-hydroxylase, which uses cholesterol and molecular oxygen as substrates and NADPH as a cofactor. 25-hydroxycholesterol is a potent bioactive lipid in the innate and adaptive immune systems[1].
[1]. McDonald JG, et al. Editorial: 25-Hydroxycholesterol: a new life in immunology. J Leukoc Biol. 2010 Dec;88(6):1071-2.
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