5-(3',4'-Dihydroxyphenyl)-γ-Valerolactone (Synonyms: (±)-δ-(3,4-Dihydroxyphenyl)-γ-Valerolactone, 5-(3',4'-Dihydroxyphenyl)-γ-VL) |
| Katalog-Nr.GC52227 |
An active metabolite of various polyphenols
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 21618-92-8
Sample solution is provided at 25 µL, 10mM.
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5-(3',4'-Dihydroxyphenyl)-γ-valerolactone is an active metabolite of various polyphenols, including (-)-epicatechin and procyanidin .1,2 It is formed from these polyphenols by gut microbiota. 5-(3',4'-Dihydroxyphenyl)-γ-valerolactone is an inhibitor of matrix metalloproteinase-1 (MMP-1) and MMP-2 collagen degradation activity (IC50s = 108 and 106 nM, respectively), MMP-1 and MMP-9 gelatin degradation activity (IC50s = 45.2 and 17.7 nM, respectively), and MMP-2 and MMP-9 elastin degradation activity (IC50s = 61.8 and 89 nM, respectively).3 It also scavenges free radicals in a Trolox equivalent antioxidant capacity (TEAC) assay.1
1.Unno, T., Tamemoto, K., Yayabe, F., et al.Urinary excretion of 5-(3',4'-dihydroxyphenyl)-γ-valerolactone, a ring-fission metabolite of (?)-epicatechin, in rats and its in vitro antioxidant activityJ. Agric. Food Chem.51(23)6893-6898(2003) 2.Appeldoorn, M.M., Vincken, J.-P., Aura, A.-M., et al.Procyanidin dimers are metabolized by human microbiota with 2-(3,4-dihydroxyphenyl)acetic acid and 5-(3,4-dihydroxyphenyl)-γ-valerolactone as the major metabolitesJ. Agric. Food Chem.57(3)1084-1092(2009) 3.Grimm, T., SchÄfer, A., and HÖgger, P.Antioxidant activity and inhibition of matrix metalloproteinases by metabolites of maritime pine bark extract (pycnogenol)Free Radic. Biol. Med.36(6)811-822(2004)
| Cas No. | 21618-92-8 | SDF | |
| Überlieferungen | (±)-δ-(3,4-Dihydroxyphenyl)-γ-Valerolactone, 5-(3',4'-Dihydroxyphenyl)-γ-VL | ||
| Canonical SMILES | OC(C(O)=C1)=CC=C1CC2CCC(O2)=O | ||
| Formula | C11H12O4 | M.Wt | 208.2 |
| Löslichkeit | DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: Slightly soluble,PBS (pH 7.2): 0.25 mg/ml | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 4.8031 mL | 24.0154 mL | 48.0307 mL |
| 5 mM | 0.9606 mL | 4.8031 mL | 9.6061 mL |
| 10 mM | 0.4803 mL | 2.4015 mL | 4.8031 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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