Atrial Natriuretic Peptide (ANP) (1-28), human, porcine (Synonyms: ANF, ANP, Atrial Natriuretic Factor, α-Atriopeptin (human)) |
| Katalog-Nr.GC34023 |
Atriales natriuretisches Peptid (ANP) (1-28), Mensch, Schwein (Atriales natriuretisches Peptid (ANP) (1-28), Mensch, Schwein) ist ein 28-AminosÄuren-Hormon, das normalerweise vom menschlichen Herzen produziert und ausgeschieden wird als Reaktion auf Herzverletzung und mechanische Dehnung.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 89213-87-6
Sample solution is provided at 25 µL, 10mM.
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Atrial Natriuretic Peptide (ANP) (1-28), human, porcine (Carperitide) is a hormone containing 28 amino acids that is produced and secreted by the heart in response to cardiac injury and mechanical stretching[1]. Carperitide is widely used in patients with Heart failure(HF)[2].
Carperitide(1 mM;10min)significantly reduced infarct size in isolated rat hearts[3]. Carperitide inhibits immunoreactive (ir)-endothelin-1 secretion and increases cyclic GMP in the human umbilical-vein endothelial cells[4].
Carperitide dose increased, coronary blood flow (CBF) increased, and coronary artery diastole reached saturation at 0.1µg kg -1 min -1, but there was no change in CPP or myocardial oxygen consumption in dog[5].
References:
[1]. Kohno M, Yokokawa K, et,al. Atrial and brain natriuretic peptides inhibit the endothelin-1 secretory response to angiotensin II in porcine aorta. Circ Res. 1992 Feb;70(2):241-7. doi: 10.1161/01.res.70.2.241. PMID: 1310444.
[2]. Mukoyama M, Nakao K, et al. Brain natriuretic peptide as a novel cardiac hormone in humans. Evidence for an exquisite dual natriuretic peptide system, atrial natriuretic peptide and brain natriuretic peptide. J Clin Invest. 1991 Apr;87(4):1402-12. doi: 10.1172/JCI115146. PMID: 1849149; PMCID: PMC295184.
[3]. Okawa H, Horimoto H, et,al.Preischemic infusion of alpha-human atrial natriuretic peptide elicits myoprotective effects against ischemia reperfusion in isolated rat hearts. Mol Cell Biochem. 2003 Jun;248(1-2):171-7. doi: 10.1023/a:1024148621505. PMID: 12870670.
[4].Kohno M, Yasunari K, et,al. Inhibition by atrial and brain natriuretic peptides of endothelin-1 secretion after stimulation with angiotensin II and thrombin of cultured human endothelial cells. J Clin Invest. 1991 Jun;87(6):1999-2004. doi: 10.1172/JCI115228. PMID: 1645748; PMCID: PMC296954.
[5].Asanuma H, Sanada S, et,al.Carperitide induces coronary vasodilation and limits infarct size in canine ischemic hearts: role of NO. Hypertens Res. 2014 Aug;37(8):716-23. doi: 10.1038/hr.2014.70. Epub 2014 Apr 3. PMID: 24694647.
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