Atrial Natriuretic Peptide (ANP) (1-28), human, porcine (Synonyms: ANF, ANP, Atrial Natriuretic Factor, α-Atriopeptin (human)) |
| カタログ番号GC34023 |
心房性ナトリウム利尿ペプチド (ANP) (1-28)、ヒト、ブタ (Atrial Natriuretic Peptide (ANP) (1-28)、ヒト、ブタ) は、28 アミノ酸のホルモンであり、通常はヒトの心臓によって産生および分泌されます。心臓損傷および機械的ストレッチに対応。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 89213-87-6
Sample solution is provided at 25 µL, 10mM.
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Atrial Natriuretic Peptide (ANP) (1-28), human, porcine (Carperitide) is a hormone containing 28 amino acids that is produced and secreted by the heart in response to cardiac injury and mechanical stretching[1]. Carperitide is widely used in patients with Heart failure(HF)[2].
Carperitide(1 mM;10min)significantly reduced infarct size in isolated rat hearts[3]. Carperitide inhibits immunoreactive (ir)-endothelin-1 secretion and increases cyclic GMP in the human umbilical-vein endothelial cells[4].
Carperitide dose increased, coronary blood flow (CBF) increased, and coronary artery diastole reached saturation at 0.1µg kg -1 min -1, but there was no change in CPP or myocardial oxygen consumption in dog[5].
References:
[1]. Kohno M, Yokokawa K, et,al. Atrial and brain natriuretic peptides inhibit the endothelin-1 secretory response to angiotensin II in porcine aorta. Circ Res. 1992 Feb;70(2):241-7. doi: 10.1161/01.res.70.2.241. PMID: 1310444.
[2]. Mukoyama M, Nakao K, et al. Brain natriuretic peptide as a novel cardiac hormone in humans. Evidence for an exquisite dual natriuretic peptide system, atrial natriuretic peptide and brain natriuretic peptide. J Clin Invest. 1991 Apr;87(4):1402-12. doi: 10.1172/JCI115146. PMID: 1849149; PMCID: PMC295184.
[3]. Okawa H, Horimoto H, et,al.Preischemic infusion of alpha-human atrial natriuretic peptide elicits myoprotective effects against ischemia reperfusion in isolated rat hearts. Mol Cell Biochem. 2003 Jun;248(1-2):171-7. doi: 10.1023/a:1024148621505. PMID: 12870670.
[4].Kohno M, Yasunari K, et,al. Inhibition by atrial and brain natriuretic peptides of endothelin-1 secretion after stimulation with angiotensin II and thrombin of cultured human endothelial cells. J Clin Invest. 1991 Jun;87(6):1999-2004. doi: 10.1172/JCI115228. PMID: 1645748; PMCID: PMC296954.
[5].Asanuma H, Sanada S, et,al.Carperitide induces coronary vasodilation and limits infarct size in canine ischemic hearts: role of NO. Hypertens Res. 2014 Aug;37(8):716-23. doi: 10.1038/hr.2014.70. Epub 2014 Apr 3. PMID: 24694647.
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