BRD 4354 |
| Katalog-Nr.GC33331 |
BRD 4354 ist ein mittelstarker Inhibitor von HDAC5 und HDAC9 mit IC50-Werten von 0,85 bzw. 1,88 μM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 315698-07-8
Sample solution is provided at 25 µL, 10mM.
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BRD 4354 is a moderately potent inhibitor of HDAC5 and HDAC9, with IC50s of 0.85 and 1.88 μM, respectively.
BRD 4354 is a moderately potent inhibitor of HDAC5 and HDAC9, with BRD4354 having half-maximum inhibitory concentrations (IC50) of 0.85 μM and 1.88 μM, respectively. BRD 4354 also inhibits HDACs 4, 6, 7, and 8 at higher concentrations (3.88-13.8 μM) but demonstrates less of an inhibitory effect on other class I HDACs 1, 2, and 3 (IC50>40 μM) [1].
[1]. Boskovic ZV, ET AL. Inhibition of Zinc-Dependent Histone Deacetylases with a Chemically Triggered Electrophile. ACS Chem Biol. 2016 Jul 15;11(7):1844-51.
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)
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