Cyclic di-UMP (sodium salt) (Synonyms: c-di-UMP, c-UpUp, Cyclic di-Uridine monophosphate, 3’3’-Cyclic UMP-UMP) |
| Katalog-Nr.GC48397 |
A pyrimidine-containing CDN
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Cyclic di-UMP is a pyrimidine-containing cyclic dinucleotide (CDN).1 It is produced by bacterial cGAS/DncV-like nucleotidyltransferases (CD-NTases), such as LpCdnE02 from L. pneumophila, and binds to cGAS, in the apo or dsDNA-bound forms, with reduced affinity compared to 2'3'-cGAMP or 3'3'-cGAMP .1,2 Cyclic di-UMP is intended for use as a negative control for cyclic di-GMP signaling.
1.Whiteley, A.T., Eaglesham, J.B., de Oliveira Mann, C.C., et al.Bacterial cGAS-like enzymes synthesize diverse nucleotide signalsNature564(7747)194-199(2019) 2.Hall, J., Ralph, E.C., Shanker, S., et al.The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibitionProtein Sci.26(12)2367-2380(2017)
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