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Disitertide (P144)

Katalog-Nr.GC34060

Disitertid (P144) (P144) ist ein peptidischer Inhibitor des transformierenden Wachstumsfaktors Beta 1 (TGF-β1), der speziell entwickelt wurde, um die Wechselwirkung mit seinem Rezeptor zu blockieren. Disitertid (P144) (P144) ist ebenfalls ein PI3K-Inhibitor und ein Apoptoseinduktor.

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Disitertide (P144) Chemische Struktur

Cas No.: 272105-42-7

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

Disitertide is an inhibitor of TGF-β1.

Disitertide (P144) prevents TGF-β1-dependent inhibition of MV1Lu proliferation in vitro and markedly reduces binding of TGF-β1 to its receptors. Disitertide blocks TGF-β1-dependent stimulation of a reporter gene under the control of human α2(I) collagen promoter[1].

Treatment with Disitertide at low doses causes a significant inhibition of HSC activation and a marked reduction in liver fibrosis in a rat model of chronic exposure to CCl4. A dose as low as 70 μg of the 15-mer peptide Disitertide, given to rats (300 g body weight) on alternate days, decreases fibrogenesis significantly during chronic exposure to CCl4[1].

[1]. Ezquerro IJ et al. A synthetic peptide from transforming growth factor beta type III receptor inhibits liver fibrogenesis in rats with carbon tetrachloride liver injury. Cytokine. 2003 Apr;22(1-2):12-20.

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