FKBP12 PROTAC dTAG-13 (Synonyms: dTAG-13) |
| Katalog-Nr.GC39264 |
FKBP12 PROTAC dTAG-13 (dTAG-13), ein PROTAC-basierter heterobifunktioneller Abbauer, ist ein selektiver Abbauer von FKBP12F36V mit Expression von FKBP12F36V im Leserahmen mit einem interessierenden Protein. FKBP12 PROTAC dTAG-13 greift effektiv in FKBP12F36V und CRBN ein, wodurch FKBP12F36V selektiv abgebaut wird.
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Cas No.: 2064175-41-1
Sample solution is provided at 25 µL, 10mM.
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FKBP12 PROTAC dTAG-13 (dTAG-13) is a PROTAC-based heterobifunctional degrader. FKBP12 PROTAC dTAG-13 (dTAG-13) is a degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-13 (dTAG-13) also is a selective degrader of BET bromodomain transcriptional co-activator BRD4 by bridging BET bromodomains to an E3 ubiquitin ligase CRBN[1].
[1]. Nabet B, et al. The dTAG system for immediate and target-specific protein degradation. Nat Chem Biol. 2018 May;14(5):431-441.
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