Duocarmycin A |
| Katalog-Nr.GC35908 |
Duocarmycin A, eines der bekannten Antitumor-Antibiotika, ist ein DNA-Alkylator und alkyliert effizient Adenin N3 am 3'-Ende von AT-reichen Sequenzen in der DNA. Duocarmycin A als Chemotherapeutikum fÜhrt bei HLC-2-Zellen typischerweise zu apoptotischen VerÄnderungen, einschließlich Chromatinkondensation, Sub-G1-Akkumulation im DNA-Histogrammmuster und Abnahme der Procaspase-3- und -9-Spiegel.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 118292-34-5
Sample solution is provided at 25 µL, 10mM.
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Duocarmycin A, which is one of well-known antitumor antibiotics, efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results HLC-2 cells typically apoptotic changes, including chromatin condensation, sub-G1 accumulation in DNA histogram pattern, and decrease in procaspase-3 and 9 levels[1]. Procaspase-3 Caspase-9
[1]. Hirota M, et al. Distamycin A enhances the cytotoxicity of duocarmycin A and suppresses duocarmycin A-induced apoptosis in human lung carcinoma cells. Int J Biochem Cell Biol. 2007;39(5):988-96.
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