PD-1-IN-22 |
Katalog-Nr.GC36862 |
PD-1-IN-22 ist ein potenter Inhibitor der Interaktion zwischen programmiertem Zelltod-1 (PD-1) und programmiertem Zelltod-Ligand 1 (PD-L1) mit einem IC50-Wert von 92,3 nM.
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Cas No.: 2349372-98-9
Sample solution is provided at 25 µL, 10mM.
PD-1-IN-22 is a potent programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) interaction inhibitor with an IC50 of 92.3 nM[1]. IC50: 92.3 nM (programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) interaction)[1]
PD-1-IN-22 dose-dependently elevates IFN-γ secretion in a co-culture model of Hep3B/OS-8/hPD-L1 and CD3 T cells[1].
[1]. Qin M, et al. Discovery of [1,2,4]Triazolo[4,3- a]pyridines as Potent Inhibitors Targeting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction. J Med Chem. 2019 May 9;62(9):4703-4715.
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