PRMT5-IN-1 |
| Katalog-Nr.GC36969 |
PRMT5 IN-1, ein Halbaminal, ist ein potenter, selektiver Inhibitor der Protein-Arginin-Methyltransferase 5 (PRMT5) mit einem IC50 von 11 nM fÜr PRMT5/MEP50. PRMT5 IN-1 kann in Aldehyde umgewandelt werden und mit C449 reagieren, um unter physiologischen Bedingungen kovalente Addukte zu bilden.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2366149-83-7
Sample solution is provided at 25 µL, 10mM.
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PRMT5 IN-1, a hemiaminal, is a covalent protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 11 nM for PRMT5/MEP50. PRMT5 IN-1 can be converted to aldehydes and react with C449 to form covalent adducts under physiological conditions[1]. IC50: 11 nM (PRMT5)[1]
[1]. https://www.ncbi.nlm.nih.gov/pubmed/31312404
Average Rating: 5 (Based on Reviews and 28 reference(s) in Google Scholar.)
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