SS28 |
| Katalog-Nr.GC37678 |
SS28, ein SRT501-Analogon mit oraler BioverfÜgbarkeit, hemmt die Tubulinpolymerisation, um einen Zellzyklusstillstand in der G2/M-Phase zu verursachen. SS28 fÜhrt eher zu Apoptose als zu Tubulinnekrose.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 141172-08-9
Sample solution is provided at 25 µL, 10mM.
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SS28, a SRT501 analog with oral bioavailability, inhibits tubulin polymerization to cause cell cycle arrest at G2/M phase. SS28 results in apoptosis rather than necrosis tubulin[1]. Tubulin[1].
SS28 (0-20 μM) induces cytotoxicity in different cancer cell lines[1].SS28 treatment (5 μM for A549 and 2 μM for CEM) results in cell cycle arrest at G2/M phase leading to apoptosis upon further incubation[1]. Cell Proliferation Assay[1] Cell Line: CEM, Reh, Nalm6, SUDHL8, Molt4, A549, HeLa 293T cells.
SS28 (15 mg/kg. b.wt.) treatment results in inhibition of tumor cell proliferation[1]. Animal Model: BALB/c mice using EAC cells[1].
[1]. Thomas E, et al. A Novel Resveratrol Based Tubulin Inhibitor Induces Mitotic Arrest and Activates Apoptosis in Cancer Cells. Sci Rep. 2016 Oct 17;6:34653.
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