PTC596 (Synonyms: Unesbulin) |
| Katalog-Nr.GC38592 |
PTC596 (PTC596) ist ein oral aktiver und selektiver B-Zell-spezifischer Inhibitor der Integrationsstelle 1 (BMI-1) des Moloney-Maus-LeukÄmievirus. PTC596 reguliert MCL-1 herunter und induziert p53-unabhÄngige mitochondriale Apoptose in Zellen der akuten myeloischen LeukÄmie (AML). PTC596 hat antileukÄmische AktivitÄt.
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Cas No.: 1610964-64-1
Sample solution is provided at 25 µL, 10mM.
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PTC596 is an orally active and selective B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) inhibitor. PTC596 targets BMI1 expressed by both tumor cells and cancer stem cells (CSCs), and induces hyper-phosphorylation of BMI1, leading to its degradation. PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia progenitor cells[1][2].
[1]. Nishida Y, et al. The novel BMI-1 inhibitor PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia progenitor cells. Blood Cancer J. 2017 Feb 17;7(2):e527. [2]. BMI1 inhibitor PTC596
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