KT 5823 |
| Katalog-Nr.GC17346 |
KT 5823, ein selektiver Inhibitor der cGMP-abhängigen Proteinkinase (PKG) mit einem Ki-Wert von 0,23 μM, hemmt auch PKA und PKC mit Ki-Werten von 10 μM bzw. 4 μM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 126643-37-6
Sample solution is provided at 25 µL, 10mM.
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The activity of cGMP-dependent protein kinase (PKG) is controlled by factors that elevate cellular cGMP, like nitric oxide (NO), and by those that reduce cGMP levels, like certain phosphodiesterases. KT 5823 is a potent, selective inhibitor of cGMP-dependent protein kinase (PKG) (in vitro IC50 = 234 nM).1 KT 5823 is cell-permeable and is often used in intact cells to assess the role of PKG in signaling, although there are cases where it poorly inhibits PKG in cells.[2] KT 5823 is a weak inhibitor of PKC (Ki = 4 µM) and PKA (Ki >10 µM).[1]
Reference:
[1]. Hidaka, H., and Kobayashi, R. Pharmacology of protein kinase inhibitors. Annu. Rev. Pharmacol. Toxicol. 32, 377-397 (1992).
[2]. Burkhardt, M., Glazova, M., Gambaryan, S., et al. KT5823 inhibits cGMP-dependent protein kinase activity in vitro but not in intact human platelets and rat mesangial cells. J. Biol. Chem. 275(43), 33536-33541 (2000).
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