Mozavaptan (hydrochloride) (Synonyms: OPC 31260) |
| Katalog-Nr.GC44247 |
Mozavaptan (Hydrochlorid) (OPC-31260-Hydrochlorid) ist ein Benzazepin-Derivat und ein potenter, selektiver, kompetitiver und oral aktiver Vasopressin-V2-Rezeptorantagonist mit einem IC50 von 14 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 138470-70-9
Sample solution is provided at 25 µL, 10mM.
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Mozavaptan is a benzazepine derivative that antagonizes the binding of arginine vasopressin (AVP) to vasopressin receptors located in the liver (V1; IC50 = 1.2 µM) and kidney (V2; IC50 = 14 nM). At 10-100 µg/kg, mozavaptan can inhibit the antidiuretic action of AVP, promoting aquaresis when administered intravenously to rats. The therapeutic potential of mozavaptan in ectopic antidiuretic hormone syndrome, heart failure, and other complications related to hyponatremia has been studied.
Average Rating: 5 (Based on Reviews and 26 reference(s) in Google Scholar.)
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