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MS21570

Katalog-Nr.GC30894

MS21570 ist ein selektiver GPR171-Antagonist mit einem IC50 von 220 nM.

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MS21570 Chemische Struktur

Cas No.: 65373-29-7

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10mM (in 1mL DMSO)
91,00 $
Auf Lager
10mg
82,00 $
Auf Lager
50mg
248,00 $
Auf Lager
100mg
423,00 $
Auf Lager

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Sample solution is provided at 25 µL, 10mM.

Description Protocol Chemical Properties Product Documents Related Products

MS21570 is a selective GPR171 antagonist, with an IC50 of 220 nM.

MS21570 significantly attenuates this CNO-mediated increase in food intake. Interestingly, MS21570 causes a significant increase in center time compared to vehicle suggesting an effect on the anxiety-like behavior. Intra-BLA administration of MS21570 leads to an increase in open arm time on the elevated plus maze although there is no effect on locomotor activity during this test. Interestingly, when administered before and immediately following fear conditioning, MS21570 significantly attenuates freezing measured 24 hours later. Behavioral differences between systemic and intra-BLA administration of MS21570 could be due to the pharmacokinetic and pharmacodynamic properties of the drug. Further studies are needed to characterize the GPR171 antagonist[1].

[1]. Bobeck EN, et al. The BigLEN-GPR171 Peptide Receptor System Within the Basolateral Amygdala Regulates Anxiety-Like Behavior and Contextual Fear Conditioning. Neuropsychopharmacology. 2017 Dec;42(13):2527-2536.

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