Pimaric Acid |
| Katalog-Nr.GC40832 |
PimarsÄure ist eine HarzsÄure, die in A.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 127-27-5
Sample solution is provided at 25 µL, 10mM.
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Pimaric acid is a resin acid that has been found in A. cordata and various pines. It reduces mRNA expression, protein levels, and promoter activity of matrix metalloproteinase-9 (MMP-9) in TNF-α-stimulated human aortic smooth muscle cells (HASMCs) in a concentration-dependent manner when used at concentrations ranging from 5 to 20 μM. Pimaric acid (10-20 μM) reduces nuclear expression and binding of the transcription factors NF-κB and AP-1 to the MMP-9 promoter in HASMCs. Pimaric acid also reduces TNF-α-induced HASMC migration to control levels when used at a concentration of 20 μg/ml.
Average Rating: 5 (Based on Reviews and 27 reference(s) in Google Scholar.)
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