Pomalidomide-PEG1-C2-N3 (Synonyms: Cereblon Ligand-Linker Conjugates 13; E3 ligase Ligand-Linker Conjugates 50) |
| Katalog-Nr.GC61200 |
Pomalidomide-PEG1-C2-N3 ist ein synthetisiertes E3-Ligase-Ligand-Linker-Konjugat, das den Pomalidomid-basierten Cereblon-Liganden und den 1-Einheit-PEG-Linker enthÄlt, der in der PROTAC-Technologie verwendet wird. Pomalidomid-PEG1-C2-N3 kann verwendet werden, um einen selektiven CDK6-PROTAC-Abbauer CP-10 zu entwerfen. CP-10 induziert den Abbau von CDK6 mit einer DC50 von 2,1 nM.
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Cas No.: 2271036-44-1
Sample solution is provided at 25 µL, 10mM.
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Pomalidomide-PEG1-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology. Pomalidomide-PEG1-C2-N3 can be used to design a selective CDK6 PROTAC degrader CP-10. CP-10 induces the degradation of CDK6 with an DC50 of 2.1 nM[1].
[1]. Su S, et al. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 2.
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