RIP2 kinase inhibitor 1 |
| Katalog-Nr.GC32775 |
RIP2-Kinase-Inhibitor 1 ist ein aktiver Metabolit von GSK2983559. RIP2-Kinase-Inhibitor 1 ist ein Rezeptor-interagierender Protein-2 (RIP2)-Kinase-Inhibitor, extrahiert aus Patent WO/2014043446 A1, Verbindungsbeispiel 1.
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Cas No.: 1423186-80-4
Sample solution is provided at 25 µL, 10mM.
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RIP2 kinase inhibitor 1 is a receptor interacting protein-2 (RIP2) kinase inhibitor extracted from patent WO/2014043446 A1, compound example 1.
RIP2 kinase inhibitor 1 is a novel prodrug of a quinazolyl amine that inhibits RIP2 kinase. Receptor interacting protein-2 (RIP2) kinase, which is also referred to as CARD3, RICK, CARDIAK, or RIPK2, is a TKL family serine/threonine protein kinase involved in innate immune signaling. RIP2 kinase is composed of an N-terminal kinase domain and a C-terminal caspase-recruitment domain (CARD) linked via an intermediate (IM) region. The CARD domain of RIP2 kinase mediates interaction with other CARD-containing proteins, such as NODI and NOD2. NODI and NOD2 are cytoplasmic receptors which play a key role in innate immune surveillance. They recognize both gram positive and gram negative bacterial pathogens and are activated by specific peptidoglycan motifs, diaminopimelic acid (i.e., DAP) and muramyl dipeptide[1].
[1]. Linda N. Casillas, et al. Prodrugs of amino quinazoline kinase inhibitor. PCT Int. Appl. (2014), WO 2014043446 A1 20140320.
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