SR 12460 |
| Katalog-Nr.GC48099 |
An IKKβ NBD mimetic
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2055101-66-9
Sample solution is provided at 25 µL, 10mM.
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SR 12460 is a mimetic of the IκB kinase β (IKKβ) NEMO/IKKγ-binding domain (NBD) that inhibits the protein-protein interaction between the IKK complex subunits NF-κB essential modulator (NEMO/IKKγ) and IKKβ.1 It inhibits TNF-α-induced NF-κB activation in a reporter assay when used at concentrations ranging from 25 to 150 µM. It reduces LPS-induced production of IL-6 in RAW 264.7 cells. SR 12460 (30 mg/kg) improves grip strength in the mdx mouse model of Duchenne muscular dystrophy.
1.Zhao, J., Zhang, L., Mu, X., et al.Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-kB activationPLoS Biol.16(6)e2004663(2018)
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
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