Ursodeoxycholic Acid (sodium salt) (Synonyms: UDCA, Ursodiol) |
| Katalog-Nr.GC45132 |
UrsodeoxycholsÄure (Ursodeoxycholat)-Natrium ist eine sekundÄre GallensÄure, die bei der Umwandlung von (Cheno)desoxycholsÄure durch Darmbakterien freigesetzt wird und als SchlÜsselregulator fÜr die IntegritÄt der Darmbarriere fungiert und fÜr den Fettstoffwechsel unerlÄsslich ist.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2898-95-5
Sample solution is provided at 25 µL, 10mM.
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Ursodeoxycholic acid (UDCA) is a secondary bile acid formed via epimerization of chenodeoxycholic acid . UDCA is also a metabolite of lithocholic acid in human liver microsomes. It inhibits taurocholic acid uptake in HeLa cells expressing recombinant sodium/taurocholate cotransporting polypeptide (NTCP) with an IC50 value of 3.6 μM. UDCA (50 μM) inhibits apoptosis induced by deoxycholic acid or ethanol in primary rat hepatocytes. Dietary administration of UDCA blocks DCA-induced increases in the number of TUNEL-positive hepatocytes in rats. Formulations containing UDCA have been used in the treatment of primary biliary cirrhosis.
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