Mefenamic Acid (Synonyms: C.I. 473, CN 35355, NSC 94437) |
| カタログ番号GC11096 |
メフェナム酸は非ステロイド性抗炎症剤であり、hCOX-1 および hCOX-2 の IC50 はそれぞれ 40 nM および 3 μM で、hCOX-1 および hCOX-2 の競合的阻害剤として作用します。
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Cas No.: 61-68-7
Sample solution is provided at 25 µL, 10mM.
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Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively.
Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively[1]. Mefenamic acid (0-100 μM) has cytotoxic effects on KB, Saos-2, and 1321N cells, however, U-87MG cells are resistant to Mefenamic acid[2].
References:
[1]. Gierse JK, et al. Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem J. 1995 Jan 15;305 (Pt 2):479-84.
[2]. Hashemipour MA, et al. In Vitro Cytotoxic Effects of Celecoxib, Mefenamic Acid, Aspirin and Indometacin on Several Cells Lines. J Dent (Shiraz). 2016 Sep;17(3):219-25.
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