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Ciliobrevin D

カタログ番号GC39359

Ciliobrevin D は、AAA+ ATPase モーター細胞質ダイニンの細胞透過性、可逆的かつ特異的な阻害剤です。 Ciliobrevin D は Hedgehog (Hh) シグナル伝達と一次繊毛形成を阻害します。シリオブレビン D は、インビトロでダイニン依存性微小管滑走および ATPase 活性を阻害します。

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Ciliobrevin D 化学構造

Cas No.: 1370554-01-0

サイズ 価格 在庫数 個数
10mM (in 1mL DMSO)
$123.00
在庫あり
1mg
$45.00
在庫あり
5mg
$112.00
在庫あり
10mg
$173.00
在庫あり
25mg
$343.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.

Product has been cited by 1 publications

Description of Ciliobrevin D

Ciliobrevin D is a cell-permeable, reversible and specific inhibitor of AAA+ ATPase motor cytoplasmic dynein. Ciliobrevin D inhibits Hedgehog (Hh) signaling and primary cilia formation. Ciliobrevin D inhibits dynein-dependent microtubule gliding and ATPase activity in vitro[1][2].

[1]. Firestone AJ, et al. Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein. Nature. 2012 Mar 18;484(7392):125-9. [2]. Miao Y, et al. Dynein promotes porcine oocyte meiotic progression by maintaining cytoskeletal structures and cortical granule arrangement. Cell Cycle. 2017;16(21):2139-2145. [3]. Wen Q, et al. Dynein 1 supports spermatid transport and spermiation during spermatogenesis in the rat testis. Am J Physiol Endocrinol Metab. 2018 Nov 1;315(5):E924-E948.

Chemical Properties of Ciliobrevin D

Cas No. 1370554-01-0 SDF
Canonical SMILES O=C(C1=C(C=C(Cl)C=C1)Cl)/C(C#N)=C(N2)/NC3=CC(Cl)=CC=C3C2=O
Formula C17H8Cl3N3O2 M.Wt 392.62
溶解度 DMSO: 5 mg/mL (12.73 mM; ultrasonic and warming and heat to 80°C) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Ciliobrevin D

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1 mg 5 mg 10 mg
1 mM 2.547 mL 12.735 mL 25.4699 mL
5 mM 0.5094 mL 2.547 mL 5.094 mL
10 mM 0.2547 mL 1.2735 mL 2.547 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Average Rating: 5 ★★★★★ (Based on Reviews and 14 reference(s) in Google Scholar.)

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