Ciliobrevin D |
| カタログ番号GC39359 |
Ciliobrevin D は、AAA+ ATPase モーター細胞質ダイニンの細胞透過性、可逆的かつ特異的な阻害剤です。 Ciliobrevin D は Hedgehog (Hh) シグナル伝達と一次繊毛形成を阻害します。シリオブレビン D は、インビトロでダイニン依存性微小管滑走および ATPase 活性を阻害します。
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Cas No.: 1370554-01-0
Sample solution is provided at 25 µL, 10mM.
Ciliobrevin D is a cell-permeable, reversible and specific inhibitor of AAA+ ATPase motor cytoplasmic dynein. Ciliobrevin D inhibits Hedgehog (Hh) signaling and primary cilia formation. Ciliobrevin D inhibits dynein-dependent microtubule gliding and ATPase activity in vitro[1][2].
[1]. Firestone AJ, et al. Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein. Nature. 2012 Mar 18;484(7392):125-9. [2]. Miao Y, et al. Dynein promotes porcine oocyte meiotic progression by maintaining cytoskeletal structures and cortical granule arrangement. Cell Cycle. 2017;16(21):2139-2145. [3]. Wen Q, et al. Dynein 1 supports spermatid transport and spermiation during spermatogenesis in the rat testis. Am J Physiol Endocrinol Metab. 2018 Nov 1;315(5):E924-E948.
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