Fexofenadine HCl (Synonyms: MDL 16455A) |
| カタログ番号GC10966 |
フェキソフェナジン (MDL-16455) 塩酸塩は、経口活性で鎮静作用のない H1 受容体拮抗薬です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 153439-40-8
Sample solution is provided at 25 µL, 10mM.
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Fexofenadine hydrochloride (MDL-16455 hydrochloride), a H1R antagonist, is an anti-allergic agent used in seasonal allergic rhinitis and chronic idiopathic urticarial (person aged ≥16 years)[1].
Fexofenadine hydrochloride (MDL-16455 hydrochloride) (100 µM; 1 hour) effectively blocks phosphorylated p38 activation in histamine-induced nasal fibroblasts[2].
Fexofenadine hydrochloride (MDL-16455 hydrochloride) (5-20 mg/kg; oral daily for 3 weeks) dose-dependently suppresses eosinophilia in C57BL/6 mice infected with T. spiralis[1].
References:
[1]. Watanabe N, et al. The effects of fexofenadine on eosinophilia and systemic anaphylaxis in mice infected with Trichinella spiralis. Int Immunopharmacol. 2004 Mar;4(3):367-75.
[2]. Park IH, et al. Histamine Promotes the Release of Interleukin-6 via the H1R/p38 and NF-κB Pathways in NasalFibroblasts. Allergy Asthma Immunol Res. 2014 Nov;6(6):567-72.
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