F-1 |
| カタログ番号GC36021 |
F-1 は強力な ALK および ROS1 二重阻害剤であり、リン酸化 ALK およびその相対的な下流のシグナル伝達経路を抑制し、ALKWT、ROS1WT、ALKL1196M、ALKG1202R の IC50 はそれぞれ 2.1 nM、2.3 nM、1.3 nM、3.9 nM です。
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Cas No.: 2244775-31-1
Sample solution is provided at 25 µL, 10mM.
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F-1 is a potent ALK and ROS1 dual inhibitor, suppresses phospho-ALK and its relative downstream signaling pathways, with IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively[1].
[1]. Guo M, et al. Dual potent ALK and ROS1 inhibitors combating drug-resistant mutants: Synthesis and biological evaluation of aminopyridine-containing diarylaminopyrimidine derivatives. Eur J Med Chem. 2018 Sep 6;158:322-333.
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
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