VP3.15 dihydrobromide |
| カタログ番号GC37924 |
VP3.15 二臭化水素酸塩は、経口で生物学的に利用可能な強力な CNS 浸透型デュアル ホスホジエステラーゼ (PDE)7-グリコーゲン シンターゼ キナーゼ (GSK)3 阻害剤であり、PDE7 と GSK-3 の IC50 はそれぞれ 1.59 μM と 0.88 μM です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1281681-33-1
Sample solution is provided at 25 µL, 10mM.
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VP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 dihydrobromide has neuroprotective and neuroreparative activities, thus as potential combined anti-inflammatory and pro-remyelinating therapies for multiple sclerosis (MS)[1]. IC50: 1.59 μM (PDE7), 0.88 μM (GSK-3)[1]
[1]. Medina-RodrÍguez EM, et al. Promoting in vivo remyelination with small molecules: a neuroreparative pharmacological treatment for Multiple Sclerosis. Sci Rep. 2017 Mar 3;7:43545.
Average Rating: 5 (Based on Reviews and 22 reference(s) in Google Scholar.)
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