Longdaysin |
| カタログ番号GC34650 |
Longdaysin は Wnt/β-カテニン シグナル伝達経路の阻害剤であり、CK1δ/ε 依存性 Wnt シグナル伝達をブロックすることで抗腫瘍効果を発揮します。 Longdaysin は CK1α、CK1δ、CDK7、ERK2 をそれぞれ 5.6 μM、8.8 μM、29 μM、52 μM の IC50 で阻害します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1353867-91-0
Sample solution is provided at 25 µL, 10mM.
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Longdaysin is a CK1α, CK1δ, and extracellular signal-regulated kinase 2 (ERK2) inhibitor with IC50s of 5.6 µM, 8.8 µM, and 52 µM, respectively[1][2]. CKIα|5.6 μM (IC50)|CKIδ|8.8 μM (IC50)|ERK2|52 μM (IC50)
[1]. 1.Griffett K, et al. The mammalian clock and chronopharmacology. Bioorganic & Medicinal Chemistry Letters, 2013, 23(7):1929-1934.. [2]. Hirota T, et al. High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase. PLoS Biol. 2010 Dec 14;8(12):e1000559.
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