SNOG (Synonyms: S-Nitroso-L-glutathione) |
| カタログ番号GC11815 |
外因性 NO 供与体であり、ラット アルコール脱水素酵素クラス III イソ酵素の基質である SNOG (GSNO) は、脳血管アンギオテンシン II 依存性および非依存性 AT1 受容体応答を阻害します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 57564-91-7
Sample solution is provided at 25 µL, 10mM.
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S-Nitroso-L-glutathione is an S-nitrosothiol NO donor based on naturally-occurring glutathione. It is a potent smooth muscle relaxant and inhibitor of platelet aggregation. Its stability in solution varies from seconds to hours depending on temperature, buffer composition, and metal content.[1][2][3][4]
Reference:
[1]. Radomski, M.W., Rees, D.D., Dutra, A., et al. S-Nitroso-glutathione inhibits platelet activation in vitro and in vivo. Br. J. Pharmacol. 107(3), 745-749 (1992).
[2] Butler, A.R., and Rhodes, P. Chemistry, analysis, and biological roles of S-nitrosothiols. Anal. Biochem. 249(1), 1-9 (1997).
[3]. Gasco, A., Fruttero, R., and Sorba, G. NO-donors: An emerging class of compounds in medicinal chemistry. Farmaco 51(10), 617-635 (1996).
[4]. Cook, J.A., Kim, S.Y., Teague, D., et al. Convenient colorimetric and fluorometric assays for S-nitrosothiols. Anal. Biochem. 238(2), 150-158 (1996).
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