2-chloro Palmitic Acid (Synonyms: 2-ClHA, 2-CLPA) |
| Catalog No.GC42135 |
염증성 지질 매개체인 2-클로로팔미트산은 단백질 팔미토일화를 방해하고, ER-스트레스 마커를 유도하고, ER ATP 함량을 감소시키며, IL-6 및 IL-8.2-클로로팔미트산의 전사 및 분비를 활성화합니다. 막 전위를 유도하고 프로카스파제-3 및 PARP 절단을 유도합니다. 2-클로로 팔미트산은 혈액-뇌 장벽(BBB)을 가로질러 인간 뇌 내피 세포주 hCMEC/D3에서 ER- 및 미토콘드리아 기능을 손상시킬 수 있습니다.
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Cas No.: 19117-92-1
Sample solution is provided at 25 µL, 10mM.
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2-chloro Palmitic acid is a monochlorinated form of palmitic acid . It is produced in a myeloperoxidase (MPO) and time-dependent manner in neutrophils stimulated by phorbol 12-myristate 13-acetate . 2-chloro Palmitic acid (10 μM) induces neutrophil extracellular trap (NET) formation (NETosis) in human neutrophils, increasing DNA release from neutrophils, colocalization of MPO with extracellular DNA (ecDNA), and trapping of E. coli. It increases COX-2 protein levels in human coronary artery endothelial cells (HCAECs) when used at a concentration of 50 μM and increases production of P-selectin, von Willebrand factor, and angiopoietin-2 in HCAECs, as well as neutrophil and platelet adherence, when used at a concentration of 10 μM. 2-chloro Palmitic acid (10-50 μM) also induces apoptosis in THP-1 cells and primary human monocytes and increases caspase-3 activity in THP-1 cells.
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