3,6-DMAD hydrochloride |
Catalog No.GC34384 |
아크리딘 유도체인 3,6-DMAD 염산염은 강력한 IRE1α-XBP1s 경로 억제제입니다. 3,6-DMAD 염산염은 IRE1α-XBP1s 경로를 통해 IL-6 분비를 촉진합니다. 3,6-DMAD 염산염은 IRE1α 올리고머화 및 엔도리보뉴클레아제(RNase) 활성을 억제합니다. 3,6-DMAD 염산염은 암 연구에 사용할 수 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
3,6-DMAD hydrochloride is a inhibitor of the IRE1α-XBP1 pathway of the unfolded protein response.
3,6-DMAD inhibits both IRE1α oligomerization and in vitro endoribonuclease (RNase) activity[1].
Following three intraperitoneal administrations of 3,6-DMAD at a dose of 10 mg/kg every 12 hours, 3,6-DMAD significantly inhibits in vivo XBP1-luciferase activity assessed 3.5 days after the initial treatment. 3,6-DMAD-treatment significantly inhibits tumor xenograft growth[1].
[1]. Jiang D, et al. Acridine Derivatives as Inhibitors of the IRE1α-XBP1 Pathway Are Cytotoxic to Human Multiple Myeloma. Mol Cancer Ther. 2016 Sep;15(9):2055-65.
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