Cucurbitacin D (Synonyms: (+)-Cucurbitacin D, Elatericin A, NSC 308606, NSC 521776) |
| Catalog No.GC35757 |
Cucurbitacin D는 Cucurbita texana의 활성 성분으로 Hsp90과 두 개의 보조 샤페론인 Cdc37 및 p23 사이의 상호 작용을 방해합니다. Cucurbitacin D는 열 충격 반응의 유도 없이 Hsp90 클라이언트(Her2, Raf, Cdk6, pAkt) 성숙을 방지합니다. 항암 활성.
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Cas No.: 3877-86-9
Sample solution is provided at 25 µL, 10mM.
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Cucurbitacin D is an active component in Cucurbita texana, disrupts interactions between Hsp90 and two co-chaperones, Cdc37 and p23. Cucurbitacin D prevents Hsp90 client (Her2, Raf, Cdk6, pAkt) maturation without induction of the heat shock response. Anti-cancer activity[1]. HSP90
[1]. Hall JA, et al. Cucurbitacin D Is a Disruptor of the HSP90 Chaperone Machinery. J Nat Prod. 2015 Apr 24;78(4):873-9.
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