Metabolism

VU534 is a NAPE-PLD activator, with an EC50 of 0.30 μM.

VU533 (APE-PLD) activator is a potent NAPE-PLD activator with an EC50 value of 0.30 µM.

PDE4-IN-14 (Compound 1) is a PDE4 inhibitor that can be used in the study of PDE4-related diseases (such as inflammatory and immune diseases, cancer, and metabolic diseases, etc.

PPARγ-IN-2 (Compound 5a) is a PPARγ inhibitor.

Opevesostat is a cholesterol side-chain cleavage enzyme (CYP11A1) inhibitor.

Dasatinib analog-1 (compound 5826) inhibits CYP3A4 viability with a Ki value of 5.4 μM.

Carbonic anhydrase inhibitor 16 (compound 1) is a dengue protease inhibitor with inhibitory activity against carbonic anhydrase hCA I and hCA II (Ki: 28.5 nM, 2.2 nM).

CA/MAO-B-IN-1 (Compound 78) is a dual inhibitor for human brain carbonic anhydrases (CA) and Monoamine Oxidase-B (MAO-B), with IC50s of 8.8 and 7.0 nM, respectively.

Ciraparantag acetate is a small-molecule, synthetic, water-soluble broad-spectrum anticoagulant reversal agent. Ciraparantag binds to and neutralizes the anticoagulant activity of unfractionated heparin, low molecular weight heparin, fondaparinux, as well as direct factor Xa inhibitors and direct thrombin inhibitors through non-covalent hydrogen bonding and charge-charge interactions, thereby restoring hemostatic function without exhibiting significant procoagulant effects.

Fuzapladib (IS-741), an orally active leukocyte-function-associated antigen type 1 (LFA-1) activation inhibitor, is a leukocyte adhesion molecule.

Otamixaban (FXV673) is a potent, selective, rapid-acting, competitive, and reversible fXa inhibitor (Ki=0.5 nM) that effectively inhibits both free and prothrombinase-bound fXa.

Dechloro Rivaroxaban is a highly selective, orally active inhibitor of Factor Xa.

Doxofylline-d6 is the deuterium labeled Doxofylline.

L-Glutathione reduced-13C2,15N is the 13C- and 15N-labeled L-Glutathione reduced.

ZY-1 is a control molecule of ZY-2 .

L-Glutamine-13C5,15N2,d5 is the deuterium, 13C-, and 15-labeled L-Glutamine.

L-Cystine-d4 is the deuterium labeled L-Cystine.

L-Cystine-34S2 is the 34S-labeled L-Cystine.

Palmitic acid-13C16 (sodium) is the 13C-labeled Palmitic acid sodium.

Palmitic acid-13C2 is the 13C-labeled Palmitic acid.

Batatasin IV is an LTA4H inhibitor with anti-inflammatory activity.

Azadiradione is a bioactive limonoid found in Azadirachta indica.

Bamadutide (SAR425899) is a potent dual glucagon-like peptide-1 receptor/glucagon receptor agonist.

Survodutide (BI 456906) is a potent, selective glucagon receptor/GLP-1 receptor (GCGR/GLP-1R) dual agonist with EC50s of 0.52 nM and 0.33 nM in CHO-K1 cells, respectively.