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P450

Cytochrome P450 are a family of heme-containing monoxygenases catalyzing the metabolism of xenobiotics in the body where P450 enzymes use O2 and two electrons provided by NAD(P)H with the help of redox partner flavoproteins and iron-sulfur proteins to catalyze the monooxygenation of a variety of substrates. Based on how electrons from NAD(P)H are delivered to the catalytic site, P450 enzymes are divided into four classes, including Class I requiring both an FAD-containing reductase and an iron sulfur redoxin, Class II requiring only an FAD/FMN-containg P450 reductase, Class III requiring no electron donor and Class IV requiring electrons directly from NAD(P)H.

  1. Cat.No. Product Name Information
  2. GC45239 δ4-Abiraterone δ4-Abiraterone (D4A) is an active metabolite of the CYP17A1 inhibitor abiraterone.
  3. GC12404 (+)-Ketoconazole Potent inhibitor of cytochrome P450c17
  4. GC30424 (-)-Cephaeline dihydrochloride (NSC 32944)
  5. GC14486 (S)-Mephenytoin

    substrate of the cytochrome P450 (CYP) isoform CYP2C19

  6. GC33073 1-Ethynylnaphthalene
  7. GC13836 2,3-dihydrothieno-Thiadiazole Carboxylate CYP450 enzymes (CYP2E1 and CYP2B4) inhibitor
  8. GC12262 2-Phenyl-2-(1-piperidinyl)propane mechanism-based inactivator of human cytochrome P450 (CYP) 2B6
  9. GC33071 4'-Methylchrysoeriol
  10. GC11758 4-phenyl-5-methyl-1,2,3-Thiadiazole CYP2B4 and CYP2E1 inhibitor
  11. GN10241 5-Methoxypsoralen Extracted from Cnidium monnieri (L.) cuss;Suitability:Boiling ethanol,acetic acid,propylene glycol,chloroform and benzene;Store the product in sealed,cool and dry condition
  12. GN10330 8-Methoxypsoralen CYP inhibitor
  13. GC17645 Abiraterone Potent CYP17 inhibitor
  14. GC11108 Abiraterone acetate

    Cytochrome p450 17a1 inhibitor

  15. GC14781 ABT (1-Aminobenzotriazole)

    Cytochrome P450 inhibitor

  16. GC16575 Alizarin

    Biological stain

  17. GC31141 Antihistamine-1
  18. GN10150 Apigenin Antioxidant plant flavanoid
  19. GC12945 Atazanavir

    HIV protease inhibitor,highly potent

  20. GC10240 Atazanavir sulfate (BMS-232632-05)

    Protease inhibitor

  21. GC10999 Avasimibe ACAT inhibitor,orally bioavailable

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