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Home >> Signaling Pathways >> Metabolism >> P450

P450

Cytochrome P450 are a family of heme-containing monoxygenases catalyzing the metabolism of xenobiotics in the body where P450 enzymes use O2 and two electrons provided by NAD(P)H with the help of redox partner flavoproteins and iron-sulfur proteins to catalyze the monooxygenation of a variety of substrates. Based on how electrons from NAD(P)H are delivered to the catalytic site, P450 enzymes are divided into four classes, including Class I requiring both an FAD-containing reductase and an iron sulfur redoxin, Class II requiring only an FAD/FMN-containg P450 reductase, Class III requiring no electron donor and Class IV requiring electrons directly from NAD(P)H.

Products for  P450

  1. Cat.No. Product Name Information
  2. GC66197 α-?Terpinyl acetate α-Terpinyl acetate is a monoterpene ester isolated from Laurus nobilis L. essential oil. α-Terpinyl acetate is a competitive P450 2B6 substrate which binding to the active site of P450 2B6 with a Kd value of 5.4 μM. α-?Terpinyl acetate Chemical Structure
  3. GC45239 δ4-Abiraterone

    CB 7627, D4A

     δ4-Abiraterone is a major metabolite of abiraterone. δ4-Abiraterone is an inhibitor of CYP17A1, 3b-hydroxysteroid dehydrogenase (3βHSD) and steroid-5a-reductase (SRD5A) and also an antagonist of androgen receptor. δ4-Abiraterone Chemical Structure
  4. GC49875 (±)-N-desmethyl Venlafaxine (hydrochloride)

    Wy 45494

     A minor active metabolite of venlafaxine (±)-N-desmethyl Venlafaxine (hydrochloride) Chemical Structure
  5. GC12404 (+)-Ketoconazole

    R 41400

     Potent inhibitor of cytochrome P450c17 (+)-Ketoconazole Chemical Structure
  6. GC30424 (-)-Cephaeline dihydrochloride (NSC 32944) (-)-Cephaeline dihydrochloride (NSC 32944) is a selective CYP2D6 inhibtor with an IC50 of 121 μM. (-)-Cephaeline dihydrochloride (NSC 32944) Chemical Structure
  7. GC14486 (S)-Mephenytoin

    (S)-5-Ethyl-3-methyl-5-phenylhydantoin

     S-Mephenytoin (5-phenyl-5-ethyl-N-methylhydantoin) is an anticonvulsive drug which is metabolized by N-demethylation and 4-hydroxylation (of the aromatic ring). (S)-Mephenytoin Chemical Structure
  8. GC33073 1-Ethynylnaphthalene 1-Ethynylnaphthalene is a selective inhibitor of cytochrome P450 1B1. 1-Ethynylnaphthalene Chemical Structure
  9. GC13836 2,3-dihydrothieno-Thiadiazole Carboxylate

    MTCC

     CYP450 enzymes (CYP2E1 and CYP2B4) inhibitor 2,3-dihydrothieno-Thiadiazole Carboxylate Chemical Structure
  10. GC12262 2-Phenyl-2-(1-piperidinyl)propane

    1-(α,α-dimethylbenzyl)-Piperidine,PPP

     mechanism-based inactivator of human cytochrome P450 (CYP) 2B6 2-Phenyl-2-(1-piperidinyl)propane Chemical Structure
  11. GC33071 4'-Methylchrysoeriol 4'-Methylchrysoeriol is a potent inhibitor of Cytochrome P450 enzymes, with an IC50 of 19 nM for human P450 1B1-dependent EROD. 4'-Methylchrysoeriol Chemical Structure
  12. GC68544 4,5-Dimethoxycanthin-6-one

    4,5-Dimethoxycanthin-6-one is an effective and non-competitive inhibitor of CYP1A2-mediated phenacetin O-deethylation, with an IC50 value of 1.7 μM and a Ki value of 2.6 μM. It is a bioactive alkaloid isolated from Picrasma quassioides BENNET (Simaroubaceae).

     4,5-Dimethoxycanthin-6-one Chemical Structure
  13. GC65517 4-(Trifluoromethyl)umbelliferone 4-(Trifluoromethyl)umbelliferone is fluorescent probe substrate for rat hepatic cytochrome P450 enzymes. 4-(Trifluoromethyl)umbelliferone Chemical Structure
  14. GC11758 4-phenyl-5-methyl-1,2,3-Thiadiazole

    NSC 358739

     CYP2B4 and CYP2E1 inhibitor 4-phenyl-5-methyl-1,2,3-Thiadiazole Chemical Structure
  15. GN10241 5-Methoxypsoralen

    5-Methoxypsoralen, 5-MOP, Heraclin, NSC 95437

     5-Methoxypsoralen Chemical Structure
  16. GC35201 8-Geranyloxypsoralen 8-Geranyloxypsoralen is a furanocoumarin isolated from grapefruit, acts as a potent inhibitor of P450 3A4 (CYP3A4) with an IC50 of 3.93 μM. 8-Geranyloxypsoralen Chemical Structure
  17. GN10330 8-Methoxypsoralen 8-Methoxypsoralen Chemical Structure
  18. GC17645 Abiraterone

    CB-7598

     A CYP17A1 inhibitor and an active metabolite of abiraterone acetate Abiraterone Chemical Structure
  19. GC11108 Abiraterone acetate

    CB-7630

     A CYP17A1 inhibitor Abiraterone acetate Chemical Structure
  20. GC64010 Abiraterone decanoate Abiraterone decanoate is a potent Abiraterone prodrug. Abiraterone decanoate provide a controlled release of Abiraterone and long-acting CYP17 inhibition with intramuscular (IM) delivery. Abiraterone decanoate Chemical Structure
  21. GC14781 ABT (1-Aminobenzotriazole)

    ABT, 3-Aminobenzotriazole, 1-Benzotriazolylamine, NSC 114498, NSC 656987

     ABT (1-Aminobenzotriazole) is a nonspecific and irreversible inhibitor of cytochrome P450 (P450). ABT (1-Aminobenzotriazole) Chemical Structure
  22. GC35236 Acetylshikonin Acetylshikonin, derived from the root of Lithospermum erythrorhizon, has anti-cancer and antiinflammation activity. Acetylshikonin Chemical Structure
  23. GC16575 Alizarin

    CI-58000, NSC 7212

     A CYP450 inhibitor Alizarin Chemical Structure
  24. GC31141 Antihistamine-1 Antihistamine-1 is a H1-antihistamine (Ki=6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel with IC50s of 5.4 and 0.8 μM, respectively. Antihistamine-1 Chemical Structure
  25. GN10150 Apigenin

    Chamomile, Flavone, NSC 83244, Versulin

     Apigenin (API), or 4′,5,7-trihydroxyflavone, is a bioactive flavonoid present in many plants, known for its anti-inflammatory, antioxidant, and anticancer properties. Apigenin Chemical Structure
  26. GC12945 Atazanavir

    BMS 232632, CGP 73547

     An inhibitor of HIV-1 protease Atazanavir Chemical Structure
  27. GC10240 Atazanavir sulfate (BMS-232632-05) An inhibitor of HIV-1 protease Atazanavir sulfate (BMS-232632-05) Chemical Structure
  28. GC65088 Atovaquone-d5

    Atavaquone-d5

     Atovaquone-d5 Chemical Structure
  29. GC10999 Avasimibe

    Cl-1011, PD-148515

     An ACAT inhibitor Avasimibe Chemical Structure
  30. GC34132 Bergamottin (5-Geranoxypsoralen)

    5-Geranoxypsoralen

     Bergamottin (5-Geranoxypsoralen) is a potent and competitive CYP1A1 inhibitor with a Ki of 10.703 nM. Bergamottin (5-Geranoxypsoralen) Chemical Structure
  31. GC33909 Bergaptol (5-Hydroxypsoralen) Bergaptol (5-Hydroxypsoralen) is a hydroxylated psoralen that acts as a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 uM. Bergaptol (5-Hydroxypsoralen) Chemical Structure
  32. GC65345 BI 653048 BI 653048 is a selective and orally active nonsteroidal?glucocorticoid (GC)?agonist with an IC50 value of 55 nM. BI 653048 Chemical Structure
  33. GC32419 BI 689648 BI 689648 is a novel, highly selective aldosterone synthase inhibitor which can inhibit CYP11B1 and CYP11B2 with IC50s of 310 and 2.1 nM, respectively. BI 689648 Chemical Structure
  34. GC31479 BMS-819881 BMS-819881 is a melaninconcentrating hormone receptor 1 (MCHR1) antagonist, which binds rat MCHR1 with a Ki of 7 nM. BMS-819881 Chemical Structure
  35. GC32257 Carbosulfan Carbosulfan inhibited relatively potently CYP3A4 and moderately CYP1A1/2 and CYP2C19 in pooled HLM (human livers). Carbosulfan Chemical Structure
  36. GC31464 CDD3505 CDD3505 is used for elevating high density lipoprotein cholesterol (HDL) by inducing hepatic cytochrome P450IIIA (CYP3A) activity. CDD3505 Chemical Structure
  37. GC31460 CDD3506 CDD3506 is used for elevating high density lipoprotein cholesterol (HDL) by inducing hepatic cytochrome P450IIIA (CYP3A) activity. CDD3506 Chemical Structure
  38. GC32991 Cecropin B Cecropin B has high level of antimicrobial activity and is considered as a valuable peptide antibiotic. Cecropin B Chemical Structure
  39. GC38681 Cedrol

    α-Cedrol

     A sesquiterpene alcohol Cedrol Chemical Structure
  40. GC16751 Chlorzoxazone

    NSC 26189

     Muscle-relaxing drug Chlorzoxazone Chemical Structure
  41. GC68863 Cholesterol 24-hydroxylase-IN-1

    Cholesterol 24-hydroxylase-IN-1 (compound 17) is a potent, orally active and highly selective inhibitor of cholesterol 24-hydroxylase (CH24H or CYP46A1) with an IC50 of 8.5 nM. Cholesterol 24-hydroxylase-IN-1 can penetrate the blood-brain barrier.

     Cholesterol 24-hydroxylase-IN-1 Chemical Structure
  42. GC11170 Choline Fenofibrate Choline Fenofibrate Chemical Structure
  43. GC35692 Chrysosplenetin

    Chrysosplenol B, Chrysosptertin B, EMD 20940, Polycladin

     A flavonoid with diverse biological activities Chrysosplenetin Chemical Structure
  44. GC16754 Clarithromycin

    A-56268, Antibiotic A 56268, TE 031

     A macrolide antibiotic Clarithromycin Chemical Structure
  45. GC38758 Clomethiazole Chlormethiazole is an potent and orally active GABAA?agonist. Clomethiazole Chemical Structure
  46. GC14269 Cobicistat (GS-9350)

    GS-9350

     An inhibitor of CYP3A Cobicistat (GS-9350) Chemical Structure
  47. GN10338 Compound K

    Ginsenoside Compound K, Ginsenoside IH901

     Compound K Chemical Structure
  48. GC41611 Curcumenol

    (+)-Curcumenol

     Curcumenol is a sesquiterpene that has been found in Curcuma species. Curcumenol Chemical Structure
  49. GC70725 CYP11B2-IN-1 CYP11B2-IN-1 is a CYP11B2 inhibitor with an IC50 of 2.3 nM. CYP11B2-IN-1 Chemical Structure
  50. GC35788 CYP17-IN-1 CYP17-IN-1 (compound 9c) is a potent and orally active CYP17 inhibitor against rat and human CYP17 with IC50s of 15.8 and 20.1 nM. CYP17-IN-1 Chemical Structure
  51. GC35803 Dafadine-A Dafadine-A, an analog of dafadine, is a novel inhibitor of DAF-9 cytochrome P450 in the nematode Caenorhabditis elegans; also inhibits the mammalian ortholog of DAF-9(CYP27A1). Dafadine-A Chemical Structure
  52. GC63872 Dagrocorat hydrochloride

    PF-00251802 hydrochloride

     Dagrocorat (PF-00251802) hydrochloride is an orally active and selective high-affinity partial agonist of the glucocorticoid receptor. Dagrocorat hydrochloride Chemical Structure
  53. GC71411 Dasatinib analog-1 Dasatinib analog-1 (compound 5826) inhibits CYP3A4 viability with a Ki value of 5.4 μM. Dasatinib analog-1 Chemical Structure
  54. GC49817 Desethoxy Quetiapine (hydrochloride)

    O-Desalkylquetiapine

     An active metabolite of quetiapine Desethoxy Quetiapine (hydrochloride) Chemical Structure
  55. GC49866 Desmethyl Carvedilol

    BM 14242, O-desmethyl Carvedilol

     An active metabolite of carvedilol Desmethyl Carvedilol Chemical Structure
  56. GC49842 Digoxigenin Bisdigitoxoside

    Bisdigoxigenin

     A Na+/K+-ATPase inhibitor Digoxigenin Bisdigitoxoside Chemical Structure
  57. GC30479 Dihydromethysticin ((+)-Dihydromethysticin)

    NSC 112159

     Dihydromethysticin ((+)-Dihydromethysticin) is one of the six major kavalactones found in the kava plant; has marked activity on the induction of CYP3A23. Dihydromethysticin ((+)-Dihydromethysticin) Chemical Structure
  58. GC16550 Diosmetin

    Diosmetol, Luteolin 4'-methyl ester

     CYP1A1 inhibitor Diosmetin Chemical Structure
  59. GC19415 DMU2105 DMU2105 is a potent and specific CYP1B1 inhibitor, with IC50s of 10 nM and 742 nM for CYP1B1 and CYP1A1, respectively. DMU2105 Chemical Structure
  60. GC19416 DMU2139 DMU2139 is a potent and specific CYP1B1 inhibitor, with IC50s of 9 nM and 795 nM for CYP1B1 and CYP1A1, respectively. DMU2139 Chemical Structure
  61. GC12892 Doxepin (hydrochloride)

    Sinequan

     histamine, serotonin, adrenergic, and muscarinic receptors antagonist Doxepin (hydrochloride) Chemical Structure
  62. GC65260 EDP-305 EDP-305 is an orally active, potent and selective farnesoid X receptor (FXR) agonist, with EC50 values of 34 nM (chimeric FXR in CHO cells) and 8 nM (full-length FXR in HEK cells). EDP-305 Chemical Structure
  63. GC35981 EMT inhibitor-2 EMT inhibitor-2 (Compound 1) inhibits epithelial-mesenchymal transition (EMT) induced by substances such as IL-1β and TGF-β released from the immunocytes. EMT inhibitor-2 Chemical Structure
  64. GC12250 Fenofibrate

    PPARα agonist

     Fenofibrate Chemical Structure
  65. GC38623 Fraxinol Fraxinol is isolated from Lobelia chinensis. Fraxinol Chemical Structure
  66. GC32855 Furafylline Furafylline, as a long-acting replacement for theophylline in the treatment of asthma, is a methylxanthine derivative. Furafylline Chemical Structure
  67. GN10137 Galangin

    NSC 407229, 3,5,7-Trihydroxyflavone

     Galangin Chemical Structure
  68. GC14915 Gemfibrozil

    CI719

     PPARα activator Gemfibrozil Chemical Structure
  69. GN10720 Gentiopicrin

    Gentiopicroside, NSC 606402

     Gentiopicrin Chemical Structure
  70. GN10032 Ginsenoside F1

    GF1, Panaxoside A Progenin

     Ginsenoside F1 Chemical Structure
  71. GN10549 Ginsenoside Rd Ginsenoside Rd Chemical Structure
  72. GC39168 GSK2945 hydrochloride GSK2945 hydrochloride is a class of tertiary amine, and is a highly specific Rev-erbα/REV-ERBα (mouse/human reverse erythroblastosis virus α) antagonist with EC50s of 21.5 μM and 20.8 μM, respectively. GSK2945 hydrochloride Chemical Structure
  73. GC49855 Harmalol (hydrochloride hydrate)

    11-hydroxy Harmalan, Harmidol

     A β-carboline alkaloid and an active metabolite of harmaline Harmalol (hydrochloride hydrate) Chemical Structure
  74. GC71313 hCYP3A4 Fluorogenic substrate 1 hCYP3A4 Fluorogenic substrate 1 is a potrnt hCYP3A4 fluorogenic substrate with an Km value of 0.36 μM. hCYP3A4 Fluorogenic substrate 1 Chemical Structure
  75. GC11540 HET0016

    N-hydroxy-N'-(4-n-butyl-2-methylphenyl)Formamidine

     inhibitor of 20-HETE formation HET0016 Chemical Structure
  76. GC49832 Hydroxymetronidazole

    hydroxy-MNZ

     Hydroxymetronidazole (Metronidazole-OH) is a metabolite of Metronidazole belonging to the class of nitroimidazoles. Hydroxymetronidazole Chemical Structure
  77. GC16707 Isavuconazole

    BAL4815, RO 0094815

     triazole antifungal drug Isavuconazole Chemical Structure
  78. GC36335 Isoglycycoumarin Isoglycycoumarin is a flavonoid isolated from the roots of Glycyrrhiza uralensis. Isoglycycoumarin Chemical Structure
  79. GN10568 Isosilybin

    Isosilibinin, Isosilybinin, Silybin B

     Isosilybin Chemical Structure
  80. GC17337 Ketoconazole

    R 41400

     A triazole antifungal agent Ketoconazole Chemical Structure
  81. GC38554 Liarozole dihydrochloride

    R75251 dihydrochloride

     Liarozole dihydrochloride is a P-450 inhibitor and retinoic acid (RA) metabolizing blocking agent inhibits RA metabolism and thereby increases intracellular RA levels in cells that actively produce RA. Liarozole dihydrochloride Chemical Structure
  82. GC67933 LKY-047 LKY-047 Chemical Structure
  83. GC70453 LY43578 LY43578 is an orally active aromatase inhibitor. LY43578 Chemical Structure
  84. GC31422 MCH-1 antagonist 1

    MCH-1 antagonist 1 is a potent melanin concentrating hormone (MCH-1) antagonist with a Ki of 2.6 nM.

     MCH-1 antagonist 1 Chemical Structure
  85. GC10198 Memantine hydrochloride

    Akatinol, Axura, Ebix, Namenda, NSC 102290, SUN Y7017

     NMDA receptor antagonist Memantine hydrochloride Chemical Structure
  86. GC41373 Methysticin

    Kavatin, (+)-Methysticin, NSC 112158

     Methysticin is a kavalactone isolated from the kava roots. Methysticin Chemical Structure
  87. GC17411 Metyrapone

    NSC 25265, SU 4885

     11-β hydroxylase (CYP11B1) inhibitor Metyrapone Chemical Structure
  88. GC16423 Monoacetylphloroglucinol

    MAPG,NSC 54927,Phloroacetophenone,2',4',6'-Trihydroxyacetophenone

     Monoacetylphloroglucinol (2,4,6-trihydroxyacetophenone) is the aglycone part of acetophenone glycoside obtained from Curcuma comosa Roxb, with cholesterol-lowering activity. Monoacetylphloroglucinol Chemical Structure
  89. GC36754 N-Nornuciferine

    Daechualkaloid E, (R)-Nornuciferine, (–)-Nornuciferine, Sanjoinine Ia

     N-Nornuciferine is an aporphine alkaloid in lotus leaf that significantly inhibits CYP2D6 with IC50 and Ki of 3.76 and 2.34 μM, respectively. N-Nornuciferine Chemical Structure
  90. GN10257 Naringin

    NSC 5548

     Naringin Chemical Structure
  91. GC49851 Norquetiapine

    N-Desalkylquetiapine

     An active metabolite of quetiapine Norquetiapine Chemical Structure
  92. GC69602 Obtusifoliol

    Obtusifoliol is a specific CYP51 inhibitor, with Kd values of 1.2 μM and 1.4 μM for the affinity to Brucella melitensis (TB) and human CYP51, respectively.

     Obtusifoliol Chemical Structure
  93. GC30966 Olivetol

    5-n-Amylresorcinol, 5-Pentylresorcinol

     Olivetol is a naturally phenol found in lichens and produced by certain insects, acting as a competitive inhibitor of the cannabinoid receptors CB1 and CB2. Olivetol Chemical Structure
  94. GC11155 Omeprazole sulfone

    OMEP sulfone, OMP sulfone, OMZ sulfone

     Omeprazole sulfone is a metabolite of Omeprazole, which is a proton pump inhibitor. Omeprazole sulfone Chemical Structure
  95. GC71393 Opevesostat Opevesostat is a cholesterol side-chain cleavage enzyme (CYP11A1) inhibitor. Opevesostat Chemical Structure
  96. GC36822 Oteseconazole

    VT-1161

     Oteseconazole (VT-1161) is an orally active anti-fungal agent, potently binds to and inhibits Candida albicans CYP51 (Kd, <39 nM), shows no obvious effect on human CYP51. Oteseconazole Chemical Structure
  97. GC12280 PF-4981517

    CYP3cide,PF-04981517,PF4981517

     A potent, selective inhibitor of CYP3A4 PF-4981517 Chemical Structure
  98. GC38421 Phillyrin (Forsythin) Phillyrin (Forsythin) is isolated from Forsythia suspensa Vahl (Oleaceae), has antibacterial and anti-inflammatory activities. Phillyrin (Forsythin) Chemical Structure
  99. GN10649 Polygalaxanthone III Polygalaxanthone III Chemical Structure
  100. GC19301 Pradefovir mesylate

    Remofovir mesylate

     Pradefovir mesylate is a good substrate for liver CYP3A4. Pradefovir mesylate Chemical Structure
  101. GC33862 Pyributicarb (TSH-888) Pyributicarb (TSH-888), a carbamate-type herbicide, is a potent activator of both CYP3A4 gene and human pregnane X receptor (hPXR). Pyributicarb (TSH-888) Chemical Structure

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