Metabolism

Theodrenaline hydrochloride is a cardiac stimulant, also acts as an anti-hypotensive agent together with Cafedrine.

Hexadecanoate-13C16 (potassium) is the 13C-labeled Hexadecanoate sodium.

Eribaxaban (PD-0348292) is an orally active and selective FXa inhibitor with a Ki value of 0.32 nM.

Luseogliflozin (TS 071) is a potent, selective, orally active sodium-dependent glucose cotransporter (SGLT) 2 inhibitor, with an IC50 of 2.26 nM, about 1765-fold selectivity over SGLT1 (IC50, 3990 nM).

Lapisteride (CS 891) is an orally active 5α-reductase inhibitor.

Cyclopentenylcytosine (CPC) is a nucleoside analog that reduces the levels of cytidine triphosphate (CTP) and deoxycytidine triphosphate (dCTP) in leukemic cells by inhibiting CTP synthetase.

EMD 53998 is a cardiotonic agent that increases myocardial contractility as an inhibitor for phosphodiesterase III (PDE III) and a calcium sensitizer.

Zelavespib (PU-H71) drochloride is a potent Hsp90 inhibitor, with an IC50 of 51 nM in MDA-MB-468 cells.

Zelavespib formic (PU-H71 formic) is a potent Hsp90 inhibitor with an IC50 value of 51 nM for Hsp90 in MDA-MB-468 cells.

1-Metladenosine-d3 drochloride is the drochloride salt form of deuterium labeled 1-Metladenosine.

HBED is a potent iron chelator.

SF2312 ammonium is the ammonium form of SF2312.

Vaxfectin is a cationic lipid-based adjuvant that can be used for plasmid DNA- and protein-based vaccines.

FTO-IN-7 is an inhibitor of FTO.

FLT3-IN-17 inhibits CYPs and FLT3 mutants activity (IC50s: <0.5 nM for D835Y).

PROTAC GPX4 degrader-1 (DC-2) is a PROTAC-based GPX4 degrader, with a DC50 of 0.03 μM in HT1080 cells.

ROS-generating agent 1 (Compound 2c) covalently modifies the Sec-498 residue of TrxR to generate ROS.

hCAIX-IN-18 (compound 30) is an inhibitor of carbonic andrase (CA), with Kis of 3.5 nM, 9.4 nM, 43.0 nM and 8.2 nM for hCAI, hCAII, hCAIX, hCAXII, respectively.

Sildenafil-d3-1 (UK-92480-d3-1) is deuterium labeled Sildenafil-d3.

5-Aminosalicylic acid-d3 is the deuterium labeled 5-Aminosalicylic Acid.

SR10221, a noncovalent inverse agonist of PPARγ, represses downstream PPARγ target genes leading to growth inhibition in bladder cancer cell lines.

VU0364739 is a selective PLD2 inhibitor (IC50: 22 nM).

Nonsteroidal aromatase inhibitor 1 (Compound 13h) is a nonsteroidal aromatase (CYP19A1) inhibitor (IC50=0.09 nM).