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Home >> Signaling Pathways >> Metabolism >> Dehydrogenase

Dehydrogenase

Dehydrogenases, belonging to the class of oxidoreductases which catalyze donor-acceptor reactions to transfer electron molecules from the oxidant to the reluctant, are a diverse group of enzymes that are able to transfer one or more hydrides (H-) from a substrate to an electron acceptor, such as nicotinamide adenine dinucleotide (NAD+), nicotinamide adenine dinucleotide phosphate (NADP+) or Riboflavin, through oxidation and reduction. Three commonly studied dehydrogenase enzymes include alcohol dehydrogenase (ADH) which catalyzes the reduction of acetylaldehyde to ethanol in plant cells, succinate dehydrogenase which oxidizes succinate to fumarate, and lactate dehydrogenase which catalyzes the reversible oxidation of lactate to pyruvate.

Products for  Dehydrogenase

  1. Cat.No. Product Name Information
  2. GC10462 6-Aminonicotinamide 6-phosphogluconate dehydrogenase inhibitor 6-Aminonicotinamide Chemical Structure
  3. GC13262 A-771726 dihydroorotate dehydrogenase inhibitor A-771726 Chemical Structure
  4. GC15601 AG-120 AG-120 (AG-120) is an orally active inhibitor of isocitrate dehydrogenase 1 mutant (mIDH1) enzyme, it exhibits profound d-2-hydroxyglutatrate (2-HG) lowering in vivo. AG-120 Chemical Structure
  5. GC25039 AG-120 (racemic) AG-120 (racemic), the racemic mixture of AG-120, is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1) with potential antineoplastic activity. AG-120 (racemic) Chemical Structure
  6. GC13147 AG-221 (Enasidenib) AG-221 (Enasidenib) is an oral, potent, reversible, selective inhibitor of the IDH2 mutant enzymes, with IC50s of 100 and 400 nM against IDH2R140Q and IDH2R172K, respectively. AG-221 (Enasidenib) Chemical Structure
  7. GC10531 AGI-5198 A potent, selective inhibitor of IDH1 mutations AGI-5198 Chemical Structure
  8. GC14757 AGI-6780 A potent, selective inhibitor of mutant IDH2 AGI-6780 Chemical Structure
  9. GC16597 Alda 1

    ALDH2 activator

     Alda 1 Chemical Structure
  10. GC15738 BVT 2733 BVT 2733 is a novel, small-molecule, nonsteroidal, isoform-selective inhibitor of 11beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) with IC50 of 96 nM (mice). BVT 2733 Chemical Structure
  11. GC13336 CBR-5884 selective inhibitor of PHGDH CBR-5884 Chemical Structure
  12. GC13611 CGP 3466B maleate CGP 3466B maleate, an orally bioavailable GAPDH nitrosylation inhibitor, abrogates Aβ1-42-induced tau acetylation, memory impairment, and locomotor dysfunction in mice. CGP 3466B maleate Chemical Structure
  13. GC14921 CPI-613 An inhibitor of α-ketoglutarate dehydrogenase CPI-613 Chemical Structure
  14. GC10902 CVT 10216 reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2) CVT 10216 Chemical Structure
  15. GC25389 Ethyl potassium malonate Ethyl potassium malonate (Potassium 3-ethoxy-3-oxopropanoate) is used as a competitive inhibitor of the enzyme succinate dehydrogenase. It acts as a precursor to produce (trimethylsilyl)ethyl malonate, which is utilized to prepare beta-ketoesters by acylation and serves as an intermediate for the preparation of ethyl tert-butyl malonate. Ethyl potassium malonate Chemical Structure
  16. GC17914 Fomepizole competitive inhibitor of the enzyme alcohol dehydrogenase Fomepizole Chemical Structure
  17. GC16816 Galloflavin human lactate dehydrogenase (LDH) inhibitor Galloflavin Chemical Structure
  18. GC17467 Gimeracil A DYPD inhibitor Gimeracil Chemical Structure
  19. GC13464 GSK 2837808A

    GSK2837808A is a selective inhibitor of lactate dehydrogenase A (LDHA) with IC50 of 2.

     GSK 2837808A Chemical Structure
  20. GC15547 Inosine-5'-monophosphate (sodium salt hydrate) substrate of IMP dehydrogenase (IMPDH) Inosine-5'-monophosphate (sodium salt hydrate) Chemical Structure
  21. GC11149 L-a-Hydroxyglutaric acid disodium salt L-a-Hydroxyglutaric acid disodium salt is an epigenetic modifier and putative oncometabolite in renal cancer. L-a-Hydroxyglutaric acid disodium salt can inhibit histone demethylases and hence promote histone methylation. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively. L-a-Hydroxyglutaric acid disodium salt Chemical Structure
  22. GC13670 Methylmalonate Methylmalonate (Methylmalonate) is an indicator of Vitamin B-12 deficiency in cancer. Methylmalonate Chemical Structure
  23. GC14415 ML390 human DHODH inhibitor ML390 Chemical Structure
  24. GC13614 Mycophenolate Mofetil A prodrug form of mycophenolic acid Mycophenolate Mofetil Chemical Structure
  25. GC16860 NCT-502 inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH) NCT-502 Chemical Structure
  26. GC15943 NCT-503

    NCT-503 is a phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 2.5 ?M

     NCT-503 Chemical Structure
  27. GC17293 PHGDH-inactive inactive analog of the 3-phosphoglycerate dehydrogenase (PHGDH) inhibitors NCT-502 and NCT-503 PHGDH-inactive Chemical Structure
  28. GC13776 Piericidin A mitochondrial complex I inhibitor Piericidin A Chemical Structure
  29. GC50508 PKUMDL WQ 2101 Negative allosteric modulator of 3-phosphoglycerate dehydrogenase (PHGDH) PKUMDL WQ 2101 Chemical Structure
  30. GC50509 PKUMDL WQ 2201 Negative allosteric modulator of 3-Phosphoglycerate dehydrogenase (PHGDH) PKUMDL WQ 2201 Chemical Structure
  31. GC17107 PluriSIn #1 (NSC 14613) A selective inhibitor of stearoyl-CoA desaturase PluriSIn #1 (NSC 14613) Chemical Structure
  32. GC15266 Qc 1 threonine dehydrogenase (TDH) inhibitor Qc 1 Chemical Structure
  33. GC16951 Stiripentol An LDH inhibitor Stiripentol Chemical Structure
  34. GC12204 STK393606 competitive inhibitor of NAD+-dependent type-I 15-hydroxy PGDH STK393606 Chemical Structure
  35. GC13760 TC HSD 21 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) inhibitor TC HSD 21 Chemical Structure
  36. GC14783 Trilostane A 3β-hydroxysteroid dehydrogenase inhibitor Trilostane Chemical Structure
  37. GC14851 Vidofludimus DHODH inhibitor Vidofludimus Chemical Structure
  38. GC10438 WIN 18446 inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2) WIN 18446 Chemical Structure

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