GLPBio

Proteases

Proteases - Signaling Pathways | GlpBio

Read More about this category

Proteases is a general term for a class of enzymes that hydrolyze protein peptide chains. According to the way they degrade polypeptides, they are divided into two categories: endopeptidases and telopeptidases. The former can cut the large molecular weight polypeptide chain from the middle to form prions and peptones with smaller molecular weights; the latter can be divided into carboxypeptidase and aminopeptidase, which respectively remove the peptide from the free carboxyl terminus or free amino terminus of the polypeptide one by one. Chain hydrolysis produces amino acids.

A general term for a class of enzymes that hydrolyze peptide bonds in proteins. According to the way they hydrolyze polypeptides, they can be divided into endopeptidases and exopeptidases. Endopeptidase cleaves the interior of the protein molecule to form smaller molecular weight peptones and peptones. Exopeptidase hydrolyzes peptide bonds one by one from the end of the free amino group or carboxyl group of protein molecules, and frees amino acids, the former is aminopeptidase and the latter is carboxypeptidase. Proteases can be classified into serine proteases, sulfhydryl proteases, metalloproteases and aspartic proteases according to their active centers and optimum pH. According to the optimum pH value of its reaction, it is divided into acidic protease, neutral protease and alkaline protease. The proteases used in industrial production are mainly endopeptidases.

Proteases are widely found in animal offal, plant stems and leaves, fruits and microorganisms. Microbial proteases are mainly produced by molds and bacteria, followed by yeast and actinomycetes.

Enzymes that catalyze the hydrolysis of proteins. There are many kinds, the important ones are pepsin, trypsin, cathepsin, papain and subtilisin. Proteases have strict selectivity for the reaction substrates they act on. A protease can only act on certain peptide bonds in protein molecules, such as the peptide bonds formed by the hydrolysis of basic amino acids catalyzed by trypsin. Proteases are widely distributed, mainly in the digestive tract of humans and animals, and are abundant in plants and microorganisms. Due to limited animal and plant resources, the industrial production of protease preparations is mainly prepared by fermentation of microorganisms such as Bacillus subtilis and Aspergillus terrestris.

Research Areas

Products Related to Proteases(4533)

  • GC79721 structure
    GC79721Substance P, free acid TFA
    Purity: >98.00%

    Substance P, Free Acid TFA is a native substance P analog, but shows no biological activity of substance P [1] .

  • GC79724 structure
    GC79724CHI3L1-IN-5
    CAS: 2249043-42-1
    Purity: >98.50%

    CHI3L1-IN-5 (Compound Z17) is a highly selective CHI3L1 inhibitor with a K D value of 6 μM.

  • GC79725 structure
    GC79725DI-1548
    CAS: 2247060-97-3
    Purity: >98%

    DI-1548 is a potent, selective, and irreversible covalent inhibitor of DCN1 ( IC 50 = 4.6 nM).

  • GC79726 structure
    GC79726Selovoxolone
    CAS: 1786406-66-3
    Purity: >98.00%

    Selovoxolone (CKBA), a derivative of AKBA is an inhibitor of acetyl-CoA carboxylase 1 ( ACC1 ), with an IC 50 of 5.02 μM.

  • GC79727 structure
    GC79727Tracer AL244
    Purity: >98.50%

    Tracer AL244 is a BODIPY-based fluorescent tracer and also a TRIM21 binder.

  • GC79728 structure
    GC79728Scytalone
    CAS: 49598-85-8
    Purity: >96.00%

    Scytalone ((+)-Scytalone) is a naphthalenone pentaketide which can be extracted from some tracheiphilous fungi.

  • GC79729 structure
    GC79729D-4'-Phosphopantothenate
    CAS: 5875-50-3
    Purity: >98%

    D-4'-Phosphopantothenate (Phosphopantothenic acid; 4'-Phosphopantothenate) serves as a precursor for coenzyme A synthesis and is a key metabolite in the biosynthetic pathway of pantothenic acid and coenzyme A.

  • GC79730 structure
    GC797302,4,6-Tribromobenzene-1,3,5-triol
    CAS: 3354-82-3
    Purity: >98.00%

    2,4,6-Tribromobenzene-1,3,5-triol is a halogenated phloroglucinol present in the red alga Rhabdonia verticillata.

  • GC79732 structure
    GC79732D-Val-Leu-Lys-AMC TFA
    Purity: >99.50%

    D-Val-Leu-Lys-AMC TFA is a selective fluorogenic peptide substrate of plasmin.

  • GC79734 structure
    GC79734Trypsin-N (MS grade)
    Purity: >98%

    Trypsin-N is a mass spectrometry-grade protease specifically designed for mass spectrometry-based enzymatic digestion of denatured proteins, suitable for LC-MS/MS analysis.

  • GC79735 structure
    GC79735Cetyl tranexamate hydrochloride
    CAS: 913541-96-5
    Purity: >99.50%

    Cetyl tranexamate (TXC) hydrochloride is an ester derivative of Tranexamic acid.

  • GC79736 structure
    GC79736Boc-Phe-Ser-Arg-AMC TFA
    Purity: >98.00%

    Boc-Phe-Ser-Arg-AMC TFA is a fluorescence peptide substrate with specificity.

  • GC79737 structure
    GC79737(S)-ZK824859 hydrochloride
    CAS: 2724549-24-8
    Purity: >98.00%

    (S)-ZK824859 hydrochloride is a uPA inhibitor and anticoagulant.

  • GC79738 structure
    GC79738Enlicitide decanoate
    CAS: 2861205-06-1
    Purity: >99.50%

    Enlicitide (MK-0616) decanoate is an orally active macrocyclic peptide PCSK9 inhibitor.

  • GC79751 structure
    GC79751UK122 hydrochloride
    Purity: >99.00%

    UK122 hydrochloride is a potent and selective urokinase-type plasminogen activator (uPA) inhibitor with an IC 50 of 0.2 μM.

  • GC79752 structure
    GC79752β-Tryptase-IN-1 free base
    CAS: 725228-45-5
    Purity: >98.00%

    β-Tryptase-IN-1 free base is a selective β-tryptase inhibitor with a K i of 10 nM.

  • GC79753 structure
    GC79753JNJ-27390467
    CAS: 1025795-12-3
    Purity: >98%

    JNJ-27390467 is a potent, orally active, and selective tryptase inhibitor ( human β-tryptase IC 50 = 3.6 nM, K i = 3.7 nM).

  • GC79754 structure
    GC79754Ac-KQKLR-AMC TFA
    CAS: 2237216-84-9
    Purity: >99.00%

    Ac-KQKLR-AMC TFA is a substrate peptide of Cathepsin S fluorescently labeled with AMC (Ex/Em=354 nm/442 nm).

  • GC79755 structure
    GC79755Phosphorylase Kinase β-Subunit Fragment (420-436) acetate
    Purity: >99.50%

    Phosphorylase Kinase β-Subunit Fragment (420-436) acetate is the β-Subunit fragment (peptide 430-436) of phosphorylase kinase.

  • GC79756 structure
    GC79756Chicken Ovomucoid
    Purity: >95.00%

    Chicken Ovomucoid is a major component of chicken ovalbumin, exhibiting trypsin inhibition and thermal stability [1] .

  • GC79757 structure
    GC79757ALOX5 stabilizer-1 TFA
    Purity: >98.00%

    ALOX5 stabilizer-1 TFA is an arachidonate 5-lipoxygenase ( ALOX5 ) stabilizer with a K d of 7.26 μM.

  • GC79758 structure
    GC79758PAI-1-IN-1
    CAS: 1247823-40-0
    Purity: >99.00%

    PAI-1-IN-1 is an orally active and specific PAI-1 inhibitor with an IC 50 of <6.95 μM.

  • GC79759 structure
    GC79759SkQR1 hydroxide
    CAS: 1333381-77-3
    Purity: >98%

    SkQR1 hydroxide is a mitochondrial targeted antioxidant.

  • GC79760 structure
    GC79760Rovunaptabin sodium
    Purity: >98.50%

    Rovunaptabin sodium (ARC 183 sodium) is a DNA aptamer, which is a single-stranded DNA molecule consisting of 15 deoxynucleotides that forms well-defined three-dimensional configuration, allowing it to bind to thrombin with high affinity and specificity.