Neuroscience
Neuroscience
Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides).
Targets for Neuroscience
- 5-HT Receptor(549)
- AChR(62)
- AChE(114)
- Alzheimer(109)
- Amyloid β(157)
- BACE(5)
- CGRP (33)
- COX(306)
- DAPK(6)
- Dopamine Receptor(319)
- GABA Receptor(239)
- Gap Junction(23)
- GluR(121)
- Histamine(4)
- Histamine Receptor(241)
- mPEGS-1(5)
- Muscarinic Receptor(46)
- Neuroscience Peptides(94)
- Nicotinic Receptor(70)
- P2 Receptor(2)
- P2X7 receptor(5)
- SSRIs(8)
- Substance P/NK1 Receptor(22)
- NMDA(2)
- Cholecystokinin Receptor(22)
- GPR139(3)
- mAChR(139)
- MCHR1 (GPR24)(15)
- Neurokinin Receptor(60)
- iGluR(139)
- nAChR(66)
- Beta-secretase(26)
- CaMK(33)
- Dopamine Transporter(17)
- Monoamine Oxidase(84)
- Serotonin Transporter(57)
- Behavioral Neuroscience(274)
- DREADD(0)
- Huntington(10)
- Neuroendocrinology(39)
- Neuroprotection(81)
- Ophthalmology(116)
- Pain Research(166)
- Parkinson(49)
- Seizure Disorders(74)
- Prion(6)
- Cholinesterases(13)
Products for Neuroscience
- Cat.No. Nombre del producto Información
- GC18022 (S)-Flurbiprofen El (S)-flurbiprofeno es un enantiÓmero activo del flurbiprofeno, con valores de IC50 de 0,48 μM y 0,47 μM para COX-1 y COX-2, respectivamente.
- GC10739 (S)-HexylHIBO Group I mGlu receptor antagonist
- GC15977 (S)-Ketoprofen El (S)-ketoprofeno es un potente inhibidor de COX-1 y COX-2 con IC50 de 1,9 y 27 nM, respectivamente.
- GC41389 (S)-Ketorolac El (S)-ketorolaco es un agente antiinflamatorio no esteroideo.
- GC41738 (S)-KT109 (S)-KT109 is the (S) isomer of the diacylglycerol lipase β (DAGLβ) inhibitor KT109.
- GC40145 (S)-Laudanosine (S)-Laudanosine is the (S) enantiomer of laudanosine, a metabolite of the neuromuscular blocking agents atracurium and cisatracurium.
- GC16349 (S)-MCPG (S)-MCPG ((+)-MCPG) es un potente antagonista del receptor metabotrÓpico de glutamato (mGluRs) del grupo I/II y el isÓmero activo de (RS)-MCPG.
- GC67989 (S)-Mirtazapine
- GC68410 (S)-Mirtazapine-d3
- GC14820 (S)-Naproxen El (S)-naproxeno es un inhibidor de COX-1 y COX-2 con IC50 de 8,72 y 5,15 μ M, respectivamente en ensayo celular.
- GC49179 (S)-O-Desmethyl Naproxen A metabolite of (S)-naproxen
- GC46355 (S)-Pramipexole-d5 (hydrochloride) An internal standard for the quantification of (S)-pramipexole
- GC33686 (S)-Rasagiline (TVP1022) (S)-rasagilina (TVP1022) (TVP1022) es la forma de enantiÓmero S relativamente inactiva de rasagilina.
- GC35006 (S)-Rasagiline mesylate El mesilato de (S)-rasagilina (TVP1022) es la forma de enantiÓmero S relativamente inactiva del mesilato de rasagilina.
-
GC69941
(S)-Renzapride
(S)-Renzapride ((S)-BRL 24924) es un isómero de Renzapride. Renzapride es un agonista del receptor 5-HT4 con un valor Ki de 115 nM. También es un antagonista de los receptores 5HT2b y 5HT3. Renzapride se puede utilizar en la investigación del síndrome del intestino irritable con estreñimiento (C-IBS).
- GC15464 (S)-SNAP 5114 (S)-SNAP 5114 es un inhibidor selectivo del transporte de GABA, con valores de IC50 de 5 μM y 21 μM para hGAT-3 y rGAT-2, respectivamente.
- GC60424 (S)-Venlafaxine (S)-venlafaxina es la configuraciÓn (S) de venlafaxina. La venlafaxina es un potente inhibidor dual de la recaptaciÓn de serotonina (5-HT)/norepinefrina (NE), activo por vÍa oral. La venlafaxina es un agente antidepresivo.
-
GC69979
(S)-VQW-765
(S)-VQW-765 ((S)-AQW-051) es un agonista parcial selectivo y efectivo del receptor de acetilcolina nicotínico (nAChR) α7 con actividad oral. (S)-VQW-765 tiene potencial aplicación en trastornos cognitivos relacionados con enfermedades neurológicas, como la enfermedad de Alzheimer o la esquizofrenia.
- GC14805 (S)-WAY 100135 dihydrochloride 5-HT1A receptor antagonist,potent and selective
-
GC30212
(S)-Willardiine ((-)-Willardiine)
(S)-Willardiine ((-)-Willardiine) es un agonista potente de los receptores AMPA/kainato con una EC50 de 44.8 uM.
- GC35011 (Z)-Thiothixene El (Z)-tiotixeno es un antagonista del receptor serotoninérgico extraÍdo de la patente US 20150141345 A1.
- GC18596 (±)-2-propyl-4-Pentenoic Acid El Ácido (±)-2-propil-4-pentenoico (4-en-VPA) es un metabolito tÓxico principal del Ácido valproico.
- GC12774 (±)-Anatoxin A fumarate (±)-Anatoxin A fumarato es un alcaloide natural aislado de cianobacterias de agua dulce.
- GC12927 (±)-Baclofen El (±)-baclofeno, un derivado lipófilo del ácido γ-aminobutírico (GABA), es un agonista metabotrópico selectivo del receptor GABAB (GABABR) activo por vía oral.
- GC11965 (±)-Huperzine A A neuroprotective AChE inhibitor
- GC13786 (±)-Salsolinol (hydrochloride) depolarize dopamineric neurons
- GC14252 (–)-Stepholidine A dopamine receptor antagonist and 5-HT1A partial agonist
- GC49034 1(R)-(Trifluoromethyl)oleyl alcohol An oleic acid analog
- GC46366 1,2,3,4-Tetrahydro-β-carboline A serotonin reuptake inhibitor and metabolite of tryptamine
- GC45698 1,2,3-Triheptanoyl-rac-glycerol El 1,2,3-triheptanoil-rac-glicerol (propano-1,2,3-triiltriheptanoato) es un triglicérido de cadena media (MCT) sintético que consta de tres Ácidos grasos de cadena impar de 7 carbonos (heptanoato) en un glicerol columna vertebral.
- GC41774 1,2,3-Trimyristoyl-rac-glycerol El 1,2,3-trimiristoil-rac-glicerol, un componente molusquicida activo de Myristica fragransHoutt, inhibe significativamente las actividades de la acetilcolinesterasa (AChE), la fosfatasa Ácida y alcalina (ACP/ALP) en el tejido nervioso de Lymnaea acuminata.
- GC46009 1,2,3-Trioctanoyl-rac-glycerol-13C3 An internal standard for the quantification of 1,2,3-trioctanoyl glycerol-13C3
- GC18334 1,2-Dierucoyl-sn-glycero-3-PC 1,2-dierucoil-sn-glicero-3-PC (DEPC) es la composiciÓn de la membrana del liposoma.
- GC42050 1-β-D-Glucosylsphingadienine (d18:2 (4E,8E)) 1-β-D-glucosilesfingadienina (d18:2 (4E,8E)) es una glucosilesfingosina, que son derivados lisolipÍdicos desacetilados de glucosilcerebrÓsidos.
- GC42051 1-β-D-Glucosylsphingosine (d18:1) 1-β-D-Glucosylsphingosine is a glucosylsphingosine, which are deacetylated lysolipid derivatives of glucocerebrosides.
- GC12587 1-(1-Naphthyl) piperazine (hydrochloride) ligand for 5-HT receptors
- GC41751 1-(3,5-Dimethylphenyl)piperazine 1-(3,5-Dimethylphenyl)piperazine is a piperidine compound that is inactive at dopamine and serotonin receptors.
- GC49346 1-(3-Chlorophenyl)biguanide (hydrochloride) A 5-HT3 receptor agonist
-
GC16031
1-(3-Chlorophenyl)piperazine (hydrochloride)
5-HT2C/2B receptor agonist/partial agonist
- GC49294 1-(4-Chlorobenzhydryl)piperazine An inactive metabolite of meclizine and chlorcyclizine
- GC41761 1-(6-Methoxy-2-naphthyl)ethanol 1-(6-Methoxy-2-naphthyl)ethanol is a potential impurity in commercial preparations of naproxen.
- GC18009 1-Acetyl-4-methylpiperazine hydrochloride nAChR agonist
- GC12863 1-BCP 1-BCP (piperidida de Ácido piperonÍlico) es un fÁrmaco centralmente activo que modula las corrientes controladas por el receptor AMPA.
- GC49861 1-Carboxycyclohexaneacetic Acid A potential impurity in commercial preparations of gabapentin
- GC46050 1-Deoxysphingosine (m18:1(4E)) An atypical sphingolipid
- GC60447 1-Hydroxy-ibuprofen El 1-hidroxiibuprofeno es un metabolito del ibuprofeno en P.
- GC14607 1-Methylpsilocin 5-HT2C agonist,potent and selective
- GC38698 1-Naphthyl acetate El acetato de 1-naftilo es un sustrato cromogénico atractivo para la detecciÓn de la actividad de la acetilcolinesterasa (AChE) de los eritrocitos.
- GC49818 1-Octen-3-ol 1-Octen-3-ol, un Ácido graso fragante, es un mensajero de oxilipina autoestimulante.
- GC40910 1-Oleoyl-2-hydroxy-sn-glycero-3-PE 1-Oleoyl-2-hydroxy-sn-glycero-3-PE is a naturally-occurring lysophospholipid and an analog of plasmalogen lysophosphatidylethanolamine.
- GC45979 1-Palmitoyl-2-Oleoyl-3-Arachidonoyl-rac-glycerol A triacylglycerol
- GC16876 1-Phenylbiguanide hydrochloride 5-HT3 receptor agonist
- GC49366 1-Salicylate Glucuronide A metabolite of salicylic acid and aspirin
- GC49088 1-Stearoyl-2-Adrenoyl-sn-glycero-3-PE A phospholipid
- GC42045 1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC 1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC is a phospholipid containing stearic acid and docosahexaenoic acid at the sn-1 and sn-2 positions, respectively.
- GC40176 1-Stearoyl-rac-glycerol 1-Stearoyl-rac-glycerol is a monoacylglycerol that contains stearic acid at the sn-1 position.
- GC49820 10,11-dihydro-10,11-dihydroxy Carbamazepine A metabolite of carbamazepine and oxcarbazepine
- GC13863 10Panx A peptide inhibitor of PANX1
- GC46412 11β-Prostaglandin F2α-d4 An internal standard for the quantification of 11β-PGF F2α
-
GC18798
11-cis Retinal
11-cis Retinal is a chromophore that binds to opsin in the mammalian visual system as an inverse agonist forming the inactive conformation of rhodopsin.
- GC48821 11-cis Retinol An isomer of vitamin A
-
GC18637
11β-Prostaglandin F2α
11β-Prostaglandin F2α (11β-PGF2α) is the primary plasma metabolite of PGD2 in vivo.
- GC49808 12-methyl Tridecanoic Acid A methylated fatty acid
- GC18783 13,14-dihydro-15-keto Prostaglandin E1 13,14-dihydro-15-keto Prostaglandin E1 (PGE1) is a metabolite of PGE1 with much reduced biological activity.
- GC41910 13-Docosenamide 13-Docosenamide is the amide of docosenoic acid.
- GC41907 13C C16 Sphingomyelin (d18:1/16:0) 13C C16 Sphingomyelin is an isotopically enriched form of C16 sphingomyelin with carbon-13 occurring on the fatty acid portion.
- GC41908 13C6 Glucosylsphingosine (d18:1) 13C6 Glucosylsphingosine (d18:1) is an isotopically enriched form of 1-β-D-glucosylsphingosine (d18:1) that is intended for use as an internal standard for the quantification of 1-β-D-glucosylsphingosine by GC- or LC-MS.
- GC46437 14-dehydro Zymostenol A cholesterol precursor
- GC40988 15(R)-17-phenyl trinor Prostaglandin F2α 17-phenyl trinor Prostaglandin F2α N-ethyl amide (17-phenyl trinor PGF2α) is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name 17-phenyl trinor PGF2α ethyl amide.
- GC41922 15(R)-17-phenyl trinor Prostaglandin F2α isopropyl ester 15(R)-17-phenyl trinor Prostaglandin F2α isopropyl ester (15(R)-17-phenyl trinor PGF2α isopropyl ester) is the latanoprost-related isomer containing both a double bond at 13,14 and an inverted (β) hydroxyl group at C-15.
- GC41093 15(S)-Latanoprost 15(S)-Latanoprost is an analog of latanoprost in which the hydroxyl at carbon 15 is inverted relative to latanoprost.
- GC49036 15-(6-nitroxyhexanoyl)-17-phenyl trinor Prostaglandin F2α A nitric oxide-donating derivative of 17-phenyl trinor prostaglandin F2α
- GC41934 15-keto Latanoprost 15-Keto latanoprost es un metabolito de Latanoprost, que es un agente hipotensor ocular.
- GC40989 15-keto Latanoprost (free acid) 15-keto Latanoprost is a potential metabolite of latanoprost when administered to animals.
- GC41936 15-keto-17-phenyl trinor Prostaglandin F2α Bimatoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug.
- GC41937 15-keto-17-phenyl trinor Prostaglandin F2α ethyl amide Bimatoprost is the Allergan trade name for 17-phenyl trinor prostaglandin F2α ethyl amide (17-phenyl trinor PGF2α ethyl amide), an F-series PG analog which has been approved for use as an ocular hypotensive drug.
- GC41947 16-phenoxy tetranor Prostaglandin F2α cyclopropyl methyl amide The actions of many clinical F-series prostaglandins (PGs), including those used for estrous synchronization and for reduction of intraocular pressure (IOP), are mediated through the PGF2α (FP) receptor.
- GC41948 16-phenoxy tetranor Prostaglandin F2α isopropyl ester Prostaglandin F2α (PGF2α) drives luteolysis and smooth muscle contraction by activating the FP receptor.
- GC40961 16-phenoxy tetranor Prostaglandin F2α methyl ester Prostaglandin F2α (PGF2α) drives luteolysis and smooth muscle contraction by activating the FP receptor.
- GC46451 16F16 A PDI inhibitor
- GC41207 17(R)-HDHA Resolvins are a group of polyhydroxylated metabolites of docosahexaenoic acid (DHA) found in the inflammatory exudates of aspirin-treated experimental animals.
- GC41208 17(S)-HDHA 17(S)-HDHA is a primary mono-oxygenation product of docosahexaenoic acid in human whole blood, human leukocytes, and mouse brain.
- GC17223 17-PA El 17-PA es un antagonista selectivo de la potenciaciÓn de neuroesteroides y la activaciÓn directa de los receptores GABAA.
- GC41960 17-phenoxy trinor Prostaglandin F2α ethyl amide Prostaglandin F2α (PGF2α), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity.
- GC40990 17-phenyl trinor Prostaglandin F2α 17-phenyl trinor Prostaglandin F2α (17-phenyl trinor PGF2α) is a metabolically stable analog of PGF2α and is a potent agonist for the FP receptor.
- GC41967 17-phenyl trinor Prostaglandin F2α amide 17-fenil trinor Prostaglandina F2α la amida es un metabolito N-desetil del bimatoprost.
- GC41969 17-phenyl trinor Prostaglandin F2α cyclopropyl amide 17-phenyl trinor Prostaglandin F2α cyclopropyl amide (17-phenyl trinor PGF2α cyclopropyl amide) is a novel analog of 17-phenyl trinor PGF2α ethyl amide.
- GC41970 17-phenyl trinor Prostaglandin F2α cyclopropyl methyl amide Prostaglandin F2α (PGF2α) activates the FP receptor, promoting smooth muscle contraction and luteolysis.
- GC41971 17-phenyl trinor Prostaglandin F2α diethyl amide 17-phenyl trinor Prostaglandin F2α diethyl amide (17-phenyl trinor PGF2α diethyl amide) is an analog of PGF2α in which the C-1 carboxyl group has been modified to an N-diethyl amide.
- GC46458 17-phenyl trinor Prostaglandin F2α dimethyl amide An isomer of 17-phenyl trinor prostaglandin F2α ethyl amide
- GC41972 17-phenyl trinor Prostaglandin F2α isopropyl ester 17-phenyl trinor PGF2α N-ethyl amide is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name Bimatoprost.
- GC41973 17-phenyl trinor Prostaglandin F2α methyl amide 17-phenyl trinor Prostaglandin F2α (17-phenyl trinor PGF2α) is a metabolically stable analog of PGF2α and is a potent agonist for the FP receptor, binding with a relative potency of 756% compared to that of PGF2α.
- GC40392 17-phenyl trinor Prostaglandin F2α methyl ester 17-fenil trinor Prostaglandina F2α El éster metÍlico es un profÁrmaco de bimatoprost.
- GC46463 17-phenyl trinor Prostaglandin F2α-d4 An internal standard for the quantification of bimatoprost (free acid)
- GC41975 17-trifluoromethylphenyl trinor Prostaglandin F2α A number of 17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives have been approved for the treatment of glaucoma.
- GC41976 17-trifluoromethylphenyl trinor Prostaglandin F2α ethyl amide Prostaglandin F2α (PGF2α), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity.
- GC41978 17-trifluoromethylphenyl trinor Prostaglandin F2α methyl ester Prostaglandin F2α (PGF2α), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity.
- GC46466 17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α A prostaglandin F derivative similar to latanoprost free acid
- GC49823 2′-C-β-Methylguanosine An active nucleoside metabolite of BMS-986094
- GC60017 2'-O-Methylisoliquiritigenin La 2'-O-metilisoliquiritigenina, aislada de la especie Arachis, regula al alza las vÍas 5-HT, NE, DA y GABA, pero no ejerce un efecto muy significativo sobre la vÍa ne NE.