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Inicio >> Signaling Pathways >> Neuroscience

Neuroscience

Neuroscience

Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides).

Targets for  Neuroscience

Products for  Neuroscience

  1. Cat.No. Nombre del producto Información
  2. GC32655 5-HT2 antagonist 1 El antagonista 1 de 5-HT2 es un potente antagonista del receptor 5-HT2, con una débil actividad bloqueadora de los adrenoceptores α1. 5-HT2 antagonist 1 Chemical Structure
  3. GC32664 5-HT2A antagonist 1 El antagonista 1 de 5-HT2A es un antagonista de 5-HT2A extraÍdo de la patente US5728835A y JP 1007727. 5-HT2A antagonist 1 Chemical Structure
  4. GC65568 5-HT2B antagonist-1 5-HT2B antagonist-1 es un antagonista del receptor 5-HT2B activo por vÍa oral con un valor IC50 de 33,4 nM. 5-HT2B antagonist-1 Chemical Structure
  5. GC31263 5-HT3 antagonist 1 El antagonista 1 de 5-HT3 es un antagonista potente y selectivo del receptor de serotonina 3 (5-HT3). 5-HT3 antagonist 1 Chemical Structure
  6. GC31247 5-HT3 antagonist 2 El antagonista 2 de 5-HT3 es un antagonista del receptor de 5-HT3. 5-HT3 antagonist 2 Chemical Structure
  7. GC65983 5-HT3 antagonist 5 El antagonista 5-HT3 5 es un compuesto de quinoxalin-2-carboxamida, un antagonista del receptor 5-HT3. El antagonista 5-HT3 ejerce antagonismo sobre el agonista 5-HT3 y el 2-metil-5-HT, y muestra un efecto antidepresivo en ratones. 5-HT3 antagonist 5 Chemical Structure
  8. GC31227 5-HT3-In-1 5-HT3-In-1 se extrae de la patente EP0748807A1, compuesto ejemplo 8. 5-HT3-In-1 Chemical Structure
  9. GC30314 5-HT4 antagonist 1 El antagonista 1 de 5-HT4 es un antagonista del receptor de 5-HT4 con un pKi de 9,6. 5-HT4 antagonist 1 Chemical Structure
  10. GC31144 5-HT7 agonist 1 El agonista 1 de 5-HT7 es un agonista selectivo del receptor de 5-HT7, con una CI50 de 222,93 nM, que se puede utilizar para enfermedades relacionadas con el receptor de 5-HT7, como los trastornos del SNC. 5-HT7 agonist 1 Chemical Structure
  11. GC49655 5-hydroxy Buspirone A metabolite of buspirone 5-hydroxy Buspirone Chemical Structure
  12. GC49119 5-hydroxy Flunixin A metabolite of flunixin 5-hydroxy Flunixin Chemical Structure
  13. GC52172 5-hydroxy Indole-3-acetic Acid-d6 5-hydroxy Indole-3-acetic Acid-d6 Chemical Structure
  14. GC49315 5-hydroxy Indomethacin A metabolite of indomethacin 5-hydroxy Indomethacin Chemical Structure
  15. GC52106 5-hydroxy Isatin An inhibitor of MAO-A 5-hydroxy Isatin Chemical Structure
  16. GC42550 5-hydroxy-6-methoxy (S)-Duloxetine 5-hydroxy-6-methoxy (S)-Duloxetine is a metabolite of (S)-duloxetine. 5-hydroxy-6-methoxy (S)-Duloxetine Chemical Structure
  17. GC42553 5-hydroxy-Nω-methyl Tryptamine (oxalate)

    5-hydroxy-Nω-methyl Tryptamine is a metabolite of serotonin in humans that has also been found in plants.

     5-hydroxy-Nω-methyl Tryptamine (oxalate) Chemical Structure
  18. GC11626 5-Iodo-A-85380 dihydrochloride α4β2 and α6β2 nicotinic acetylcholine receptors agonist 5-Iodo-A-85380 dihydrochloride Chemical Structure
  19. GC14225 5-Iodo-A-85380, 5-trimethylstannyl N-BOC derivative Precursor to ligand for the α4β2 nicotinic receptor 5-Iodo-A-85380, 5-trimethylstannyl N-BOC derivative Chemical Structure
  20. GC14940 5-Methoxytryptamine 5-Methoxytryptamine Chemical Structure
  21. GC64182 5-Methoxytryptamine hydrochloride 5-Methoxytryptamine hydrochloride Chemical Structure
  22. GC14604 5-Methylfurmethiodide muscarinic agonist 5-Methylfurmethiodide Chemical Structure
  23. GC46706 5-Methyltetrahydrofolic Acid (hydrate) A biologically active form of folic acid 5-Methyltetrahydrofolic Acid (hydrate) Chemical Structure
  24. GC17477 5-Nonyloxytryptamine oxalate 5-HT1B agonist 5-Nonyloxytryptamine oxalate Chemical Structure
  25. GC41156 5-Octyl D-glutamate 5-Octyl D-glutamate, also known as 5-octyl ester D-glutamate, is a stable, cell-permeable molecule that generates free D-glutamate upon hydrolysis of the ester bond by cytoplasmic esterases. 5-Octyl D-glutamate Chemical Structure
  26. GC41094 5-trans Latanoprost Latanoprost is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug. 5-trans Latanoprost Chemical Structure
  27. GC41228 5-trans Latanoprost (free acid) Latanoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug. 5-trans Latanoprost (free acid) Chemical Structure
  28. GC49438 5-trans-17-phenyl trinor Prostaglandin F2α The 5-trans isomer of 17-phenyl trinor PGF2α 5-trans-17-phenyl trinor Prostaglandin F2α Chemical Structure
  29. GC31296 5HT6-ligand-1 5HT6-ligand-1 es un potente ligando del receptor 5-HT6 con una Ki de 1,43 nM. 5HT6-ligand-1 Chemical Structure
  30. GC18176 5α,6β-Dihydroxycholestanol 5α,6β-Dihydroxycholestanol is an oxysterol metabolite of cholesterol formed from conversion of cholesterol epoxides by 5,6-epoxysterol hydrolase. 5α,6β-Dihydroxycholestanol Chemical Structure
  31. GC30943 6,2'-Dihydroxyflavone La 6,2'-dihidroxiflavona es un nuevo antagonista del receptor GABAA. 6,2'-Dihydroxyflavone Chemical Structure
  32. GC46720 6,9-Dichloro-1,2,3,4-tetrahydroacridine A synthetic intermediate in the synthesis of AChE inhibitors 6,9-Dichloro-1,2,3,4-tetrahydroacridine Chemical Structure
  33. GC11284 6-(4-Methoxyphenyl)-3-pyridazinamine GABAA receptor antagonist 6-(4-Methoxyphenyl)-3-pyridazinamine Chemical Structure
  34. GC42572 6-Amino-8-trifluoromethylphenanthridine 6-Amino-8-trifluoromethylphenanthridine (6A-8tFP) is an antiprion agent and a derivative of 6-aminophenanthridine. 6-Amino-8-trifluoromethylphenanthridine Chemical Structure
  35. GC40479 6-Aminophenanthridine La 6-aminofenantridina inhibe la actividad de plegamiento de proteÍnas del ribosoma (PFAR). 6-Aminophenanthridine Chemical Structure
  36. GC14000 6-fluoro-DL-Tryptophan El 6-fluoro-DL-triptÓfano es un potente inhibidor competitivo de la triptÓfano hidroxilasa. 6-fluoro-DL-Tryptophan Chemical Structure
  37. GC42580 6-hydroxy Chlorzoxazone

    6-hydroxy Chlorzoxazone is a metabolite of chlorzoxazone.

     6-hydroxy Chlorzoxazone Chemical Structure
  38. GC49183 6-hydroxy Etodolac A metabolite of etodolac 6-hydroxy Etodolac Chemical Structure
  39. GC16267 6-Hydroxydopamine hydrobromide El hidrobromuro de 6-hidroxidopamina (6-OHDA) es un análogo estructural de las catecolaminas, dopamina y noradrenalina, y ejerce sus efectos tóxicos sobre las neuronas catecolaminérgicas. 6-Hydroxydopamine hydrobromide Chemical Structure
  40. GC16153 6-methoxy Naphthalene Acetic Acid competitive, non-selective COX inhibitor 6-methoxy Naphthalene Acetic Acid Chemical Structure
  41. GC31309 6-Methoxy-2-naphthoic acid (Naproxen impurity O) El Ácido 6-metoxi-2-naftoico (impureza O de naproxeno) es un modulador del receptor NMDA extraÍdo de la patente WO 2012019106 A2. 6-Methoxy-2-naphthoic acid (Naproxen impurity O) Chemical Structure
  42. GC30898 6-Methylflavone La 6-metilflavona es un activador de los receptores α1β2γ2L y α1β2 GABAA. 6-Methylflavone Chemical Structure
  43. GC42584 6-O-desmethyl Donepezil 6-O-desmethyl Donepezil is an active metabolite of the acetylcholinesterase inhibitor donepezil. 6-O-desmethyl Donepezil Chemical Structure
  44. GC10781 7-Chlorokynurenic acid El Ácido 7-cloroquinurénico (7-CKA) es un antagonista potente y selectivo del sitio coagonista de glicina B del receptor N-metil-D-aspartato (NMDA) (IC50 = 0,56 μM). 7-Chlorokynurenic acid Chemical Structure
  45. GC11395 7-Chlorokynurenic acid sodium salt La sal sÓdica del Ácido 7-cloroquinurénico (sal sÓdica de 7-CKA) es un antagonista potente y selectivo del sitio coagonista de glicina B del receptor N-metil-D-aspartato (NMDA) (IC50 = 0,56 μM). 7-Chlorokynurenic acid sodium salt Chemical Structure
  46. GC46242 7-dehydro Cholesterol-d7

    7-dehydro Cholesterol (7-DHC) is an immediate precursor of cholesterol

     7-dehydro Cholesterol-d7 Chemical Structure
  47. GC48649 7-hydroxy Chlorpromazine (hydrochloride) An active metabolite of chlorpromazine 7-hydroxy Chlorpromazine (hydrochloride) Chemical Structure
  48. GC35192 7-Hydroxy-3,4-dihydro-2(1H)-quinolinone La 7-Hidroxi-3,4-dihidro-2(1H)-quinolinona (3,4-Dihidro-7-hidroxi-2(1H)-quinolinona) es un inhibidor débil de la MAO-A, con un IC50 de 183 μM, y no tiene efecto sobre MAO-B. 7-Hydroxy-3,4-dihydro-2(1H)-quinolinone Chemical Structure
  49. GC16574 7-Hydroxy-DPAT hydrobromide D3 dopamine receptor agonist 7-Hydroxy-DPAT hydrobromide Chemical Structure
  50. GC40572 7-keto Cholesterol El colesterol 7-ceto, oxisterol tóxico, inhibe el paso limitante de la biosíntesis de ácidos biliares colesterol 7 alfa-hidroxilasa, así como también inhibe fuertemente la HMG-CoA reductasa (la enzima limitante de la biosíntesis del colesterol). 7-keto Cholesterol Chemical Structure
  51. GC46241 7-keto Cholesterol-d7

    7-keto Cholesterol is a bioactive sterol and a major oxysterol component of oxidized LDL

     7-keto Cholesterol-d7 Chemical Structure
  52. GC48880 7-Methoxyflavone La 7-metoxiflavona es un compuesto aislado de Zornia brasiliensis. 7-Methoxyflavone Chemical Structure
  53. GC15338 8,11,14-Eicosatriynoic Acid A Cox, 12-LO, and 5-LO inhibitor 8,11,14-Eicosatriynoic Acid Chemical Structure
  54. GC40587 8,12-iso-iPF2α-VI 8,12-iso-iPF2α-VI is an isoprostane produced by non-enzymatic, free radical-induced peroxidative damage to membrane lipids. 8,12-iso-iPF2α-VI Chemical Structure
  55. GC49017 8-hydroxy Amoxapine A metabolite of amoxapine 8-hydroxy Amoxapine Chemical Structure
  56. GC42626 8-hydroxy Efavirenz 8-hydroxy Efavirenz is a major oxidative metabolite of the non-nucleoside reverse transcriptase inhibitor efavirenz. 8-hydroxy Efavirenz Chemical Structure
  57. GC18654 8-hydroxy Loxapine 8-hydroxy Loxapine (8-OH loxapine) is a metabolite formed when loxapine , an atypical antipsychotic, is metabolized by the cytochrome P450 isoform CYP1A2. 8-hydroxy Loxapine Chemical Structure
  58. GC49544 8-hydroxy Mirtazapine A metabolite of mirtazapine 8-hydroxy Mirtazapine Chemical Structure
  59. GC14966 8-Hydroxy-DPAT hydrobromide El bromhidrato de 8-hidroxi-DPAT (bromhidrato de 8-OH-DPAT) es un agonista de 5-HT1A potente y selectivo con una pIC50 de 8,19. 8-Hydroxy-DPAT hydrobromide Chemical Structure
  60. GC12427 8-Hydroxy-PIPAT oxalate 5-HT1A receptor agonist 8-Hydroxy-PIPAT oxalate Chemical Structure
  61. GC40759 8-methyl Nonanoic Acid

    Capsaicin, the chemical that imparts the spicy-hot quality of chili peppers, is produced by the fruits of plants belonging to the Capsicum family.

     8-methyl Nonanoic Acid Chemical Structure
  62. GC30888 8-OH-DPAT (8-Hydroxy-DPAT) 8-OH-DPAT (8-Hydroxy-DPAT) es un agonista de 5-HT potente y selectivo, con una pIC50 de 8,19 para 5-HT1A y una Ki de 466 nM para 5-HT7; 8-OH-DPAT (8-Hydroxy-DPAT) se une débilmente a 5-HT1B (pIC50, 5,42), 5-HT (pIC50 <5). 8-OH-DPAT (8-Hydroxy-DPAT) Chemical Structure
  63. GC46753 9(S),12(S),13(S)-TriHOME An oxylipin 9(S),12(S),13(S)-TriHOME Chemical Structure
  64. GC42640 9(Z),12(Z),15(Z),18(Z),21(Z)-Tetracosapentaenoic Acid 9(Z),12(Z),15(Z),18(Z),21(Z)-Tetracosapentaenoic acid is an ω-3 very long-chain polyunsaturated fatty acid. 9(Z),12(Z),15(Z),18(Z),21(Z)-Tetracosapentaenoic Acid Chemical Structure
  65. GC14302 9,12-Octadecadiynoic Acid El Ácido 9,12-octadecadiinoico (Ácido 9a,12a-octadecadiinoico) es un inhibidor de la lipoxigenasa vegetal. 9,12-Octadecadiynoic Acid Chemical Structure
  66. GC13537 A 331440 dihydrochloride H3 receptor antagonist,non-imidazole,high affinity A 331440 dihydrochloride Chemical Structure
  67. GC14610 A 412997 dihydrochloride Selective D4 agonist A 412997 dihydrochloride Chemical Structure
  68. GC12739 A 484954 A 484954 es un inhibidor del factor de elongación 2 eucariota altamente selectivo (eEF2), con una IC50 de 280 nM. A 484954 Chemical Structure
  69. GC17805 A 582941 A 582941 es un agonista parcial potente, selectivo y que penetra en el cerebro de α7 nAChR, con Kis de 10,8 y 16,7 nM en membranas de cerebro de rata y corteza frontal humana, respectivamente. A 582941 Chemical Structure
  70. GC15498 A 68930 hydrochloride El clorhidrato de 68930, como agonista del receptor de dopamina D1, se puede utilizar para la investigación de las bronquiectasias. A 68930 hydrochloride Chemical Structure
  71. GC11183 A 77636 hydrochloride Un clorhidrato de 77636 es un potente agonista del receptor de dopamina D1, activo por vía oral, selectivo y de acción prolongada (pKi \u003d 7,40; Ki \u003d 39,8 nM) con actividad antiparkinsoniana. A 77636 hydrochloride Chemical Structure
  72. GC15434 A 839977 A 839977 es un antagonista selectivo de P2X7; bloquea la entrada de calcio provocada por BzATP en los receptores P2X7 humanos, de rata y de ratÓn recombinantes (los valores de IC50 son 20 nM, 42 nM y 150 nM respectivamente) y reduce el dolor inflamatorio y neuropÁtico en modelos animales; los efectos antihiperalgésicos del bloqueo del receptor P2X7 estÁn mediados por el bloqueo de la liberaciÓn de IL-1beta. A 839977 Chemical Structure
  73. GC16068 A 841720 A 841720 es un antagonista del receptor mGlu1 potente, no competitivo y selectivo con una IC50 de 10 nM para el receptor mGlu1 humano. A 841720 Chemical Structure
  74. GC15333 A 844606 α7 nAChR partial agonist A 844606 Chemical Structure
  75. GC11121 A 943931 dihydrochloride Antagonist of histamine H4 receptor,potent and selective A 943931 dihydrochloride Chemical Structure
  76. GC17743 A 987306 A 987306 es un potente antagonista de histamina H4 biodisponible por vía oral, con Kis de 3,4 nM y 5,8 nM para H4 de rata y H4 humano. A 987306 Chemical Structure
  77. GC63502 Aβ/tau aggregation-IN-1 Aβ/tau aggregation-IN-1 es un potente inhibidor de la formaciÓn de lÁminas y de la agregaciÓn de tau. Aβ/tau aggregation-IN-1 Chemical Structure
  78. GC60037 A-3 hydrochloride El clorhidrato de A-3 es un potente antagonista no selectivo de varias quinasas, permeable a las células, reversible y competitivo con ATP. A-3 hydrochloride Chemical Structure
  79. GC19499 A-381393 A-381393 es un antagonista del receptor de dopamina D4 potente, selectivo, que penetra en el cerebro, con Kis de 1.5, 1.9 y 1.6 nM para el receptor de dopamina humano D4.4, D4.2 y D4.7, respectivamente, selectividad >2700 veces mayor que Receptores de dopamina D1, D2, D3 y D5. A-381393 Chemical Structure
  80. GC31214 A-437203 (Lu201640) A-437203 (Lu201640) es un antagonista selectivo del receptor D3 con Ki de 71, 1,6 y 6220 nM para los receptores D2, D3 y D4, respectivamente. A-437203 (Lu201640) Chemical Structure
  81. GC11842 A-740003 A selective P2X7 antagonist A-740003 Chemical Structure
  82. GC15014 A-867744 A positive allosteric modulator of α7 nAChRs A-867744 Chemical Structure
  83. GC10641 AA 29504 GABAA receptor modulator AA 29504 Chemical Structure
  84. GC31055 Abaperidone La abaperidona es un potente antagonista del receptor 5-HT2A y del receptor D2 de dopamina con IC50 de 6,2 y 17 nM. Abaperidone Chemical Structure
  85. GC42674 ABD459 ABD459 is a neutral antagonist of the central cannabinoid 1 (CB1) receptor (Ki = 8.6 nM). ABD459 Chemical Structure
  86. GC11795 ABT 724 trihydrochloride El trihidrocloruro de ABT 724 es un agonista del receptor de dopamina D4 potente y altamente selectivo con una CE50 de 12,4 nM para el receptor de dopamina D4 humano. ABT 724 trihydrochloride Chemical Structure
  87. GC35222 ABT-239 ABT-239 es una clase de antagonista H3R novedoso, altamente eficaz, que no es de imidazol y un antagonista de potencial receptor transitorio vaniloide tipo 1 (TRPV1). ABT-239 Chemical Structure
  88. GC33552 ABT-670 ABT-670 es un agonista biodisponible oral selectivo del receptor de dopamina D4, con EC50 de 89 nM, 160 nM y 93 nM para humanoD4, hurÓnD4 y rataD4, respectivamente. ABT-670 Chemical Structure
  89. GP10121 Ac-Endothelin-1 (16-21), human Ac-Endothelin-1 (16-21), human Chemical Structure
  90. GC42721 Ac-YVAD-CMK Ac-YVAD-CMK es una inhibición caspase-1 (Ki=0.8nM) que sin reversibilidad selectivacaspase-1 (Ki=0.8nM), se puede impedir la actividad de citoquinas proinflamatorias IL-1β. Ac-YVAD-CMK puede reducir la información e induce efectos neuroprotectores duraderos. Ac-YVAD-CMK Chemical Structure
  91. GC49263 Ac2-26 (human) (ammonium salt) An annexin A1-mimetic peptide Ac2-26 (human) (ammonium salt) Chemical Structure
  92. GC30859 AC260584 AC260584 es un agonista alostérico del receptor muscarÍnico M1 con un pEC50 de 7,6. AC260584 Chemical Structure
  93. GC14916 Acamprosate calcium An NMDA modulator Acamprosate calcium Chemical Structure
  94. GC46778 Acamprosate-d3 (calcium salt) An internal standard for the quantification of acamprosate Acamprosate-d3 (calcium salt) Chemical Structure
  95. GC17079 ACDPP hydrochloride mGlu5 receptor antagonist ACDPP hydrochloride Chemical Structure
  96. GC64332 Aceclidine La aceclidina es un modulador del receptor muscarÍnico de acetilcolina M3. Aceclidine Chemical Structure
  97. GC12787 Aceclidine (hydrochloride) agonist of muscarinic receptors Aceclidine (hydrochloride) Chemical Structure
  98. GC15902 Aceclofenac El aceclofenaco es un fÁrmaco antiinflamatorio no esteroideo (AINE) activo por vÍa oral, con propiedades analgésicas y antiinflamatorias. Aceclofenac Chemical Structure
  99. GC42691 Aceclofenac ethyl ester A potential impurity found in commercial preparations of aceclofenac Aceclofenac ethyl ester Chemical Structure
  100. GC42692 Aceclofenac methyl ester A potential impurity in commercial preparations of aceclofenac Aceclofenac methyl ester Chemical Structure
  101. GC10454 Acemetacin La acemetacina (TVX 1322) es un fÁrmaco antiinflamatorio no esteroideo y un éster de Ácido glicÓlico de indometacina que es un inhibidor de la ciclooxigenasa. Acemetacin Chemical Structure

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