CAY10568 (Synonyms: Santinamide) |
| Katalog-Nr.GC43171 |
Most local anesthetics act by abolishing voltage gated sodium channel currents indiscriminately in all populations of neurons.
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Cas No.: 22913-17-3
Sample solution is provided at 25 µL, 10mM.
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Most local anesthetics act by abolishing voltage gated sodium channel currents indiscriminately in all populations of neurons. Selective analgesia through TRPV1-mediated entry of a cationic lidocaine derivative, QX314, was recently reported. CAY10568 is a physically smaller, less hydrophobic version of QX314 designed to be even more permeable to TRPV1 ion channel when activated by agonists such as capsaicin and N-oleoyl dopamine. CAY10568 when given in combination with suitable TRPV1 agonists should produce selective blockade of the pain response while leaving motor, touch, and proprioception intact.
Average Rating: 5 (Based on Reviews and 20 reference(s) in Google Scholar.)
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