Iristectorin B |
Katalog-Nr.GC36331
One-Click Copy Product Info
|
Iristectorin B ist ein Isoflavon aus Iris tectorum und hat krebshemmende AktivitÄten bei Brustkrebs.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 94396-09-5
Sample solution is provided at 25 µL, 10mM.
_1-3.$$$39978408@51.jpg');)
_1-9.$$$38538795@65.jpg');)
_1-9.$$$39112701@51.jpg');)
_1-7.$$$37316672@70.jpg');)
_366-372.$$$36198801@70.jpg');)
.$$$38565142@65.jpg');)
_1867-1883.$$$33248023@67.jpg');)
_eads6055.$$$39977546@45.jpg');)
_eadm9805.$$$40080571@45.jpg');)
_eadj3020.$$$39666821@45.jpg');)
_1-20.$$$39757301@28.jpg');)
_1-24.$$$38898113@28.jpg');)
_273-287.$$$36806353@46.jpg');)
_1-16.$$$37156877@44.jpg');)
_1-19.$$$37460805@44.jpg');)
_1291-1307.$$$34518654@46.jpg');)
Iristectorin B is a natural isoflavone from Iris tectorum with anticancer effects [1]. Iristectorin B can exert anti-inflammatory activity by inhibiting the production of NO induced by lipopolysaccharide (LPS)[2]. Iristectorin B is widely used as an internal reference to develop ionic liquid ultrasonic-assisted extraction methods for the extraction and separation of related compounds[3].
In vitro, Iristectorin B (25µM) treatment for 24 hours significantly enhanced the survival of PC12 cells after glucose oxygen deprivation/reoxygenation (OGD/R) treatment, reduced cell apoptosis, and significantly decreased the expressions of TFR1, HMOX1, and SLC3A2[4].
References:
[1] Ruan L J, Yan B X, Wu Y Q, et al. Integrated Chemometric and Spectrum-effect analysis discriminates Belamcanda chinensis and Iris tectorum in treating A549 lung Cancer cells[J]. Journal of Chromatography B, 2025: 124875.
[2] Gao B, Ma Y, Zhang L, et al. Identification and characterization of the chemical components of Iris tectorum Maxim. and evaluation of their nitric oxide inhibitory activity[J]. Rapid communications in mass spectrometry, 2021, 35(1): e8959.
[3] Sun Y, Li W, Wang J. Ionic liquid based ultrasonic assisted extraction of isoflavones from Iris tectorum Maxim and subsequently separation and purification by high-speed counter-current chromatography[J]. Journal of Chromatography B, 2011, 879(13-14): 975-980.
[4] Zheng M, Zhou M, Lu T, et al. TMT and PRM Based Quantitative Proteomics to Explore the Protective Role and Mechanism of Iristectorin B in Stroke[J]. International Journal of Molecular Sciences, 2023, 24(20): 15195.
| Cell experiment [1]: | |
Cell lines | PC12 cells |
Preparation Method | PC12 cells were cultured in high-glucose DMEM medium supplemented with 10% fetal bovine serum (FBS) and 1% Penicillin/Streptomycin at 37℃ in the presence of 5% CO2. 100μl of sugar-free EBSS solution containing 10mM Na2S2O4 was added and incubated for 2h. The cells were replaced with normal medium for reoxygenation and continued to be cultured for 24h, constituting an induced OGD/R injury model to simulate ischemic brain injury. OGD/R was supplemented with normal culture medium containing Iristectorin B 6.25µM, 12.5µM, and 25µM for 24h. The, cell viability was analyzed. |
Reaction Conditions | 6.25µM, 12.5µM, and 25µM; 24h |
Applications | Iristectorin B treatment enhanced the cell viability of PC12 cells after OGD/R injury. |
| Cas No. | 94396-09-5 | SDF | |
| Canonical SMILES | O=C1C(C2=CC=C(O)C(OC)=C2)=COC3=CC(O[C@@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)=C(OC)C(O)=C13 | ||
| Formula | C23H24O12 | M.Wt | 492.43 |
| Löslichkeit | Soluble in DMSO | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.0307 mL | 10.1537 mL | 20.3075 mL |
| 5 mM | 406.1 μL | 2.0307 mL | 4.0615 mL |
| 10 mM | 203.1 μL | 1.0154 mL | 2.0307 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 6 reference(s) in Google Scholar.)