NSC16168 |
| Katalog-Nr.GC36775 |
NSC16168 ist ein spezifischer Inhibitor von ERCC1-XPF mit einem IC50-Wert von 0,42 μM. NSC16168 hemmt die DNA-Reparatur und verstÄrkt die Wirksamkeit von CDDP bei Krebs.
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Cas No.: 6837-93-0
Sample solution is provided at 25 µL, 10mM.
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NSC16168 is a specific inhibitor of ERCC1-XPF, with an IC50 value of 0.42 μM. NSC16168 inhibits DNA repair and potentiates CDDP efficacy in cancer[1]. IC50: 0.42 μM (ERCC1-XPF)[1].
[1]. Arora S, et al. Identification of small molecule inhibitors of ERCC1-XPF that inhibit DNA repair and potentiate cisplatin efficacy in cancer cells. Oncotarget. 2016 Nov 15;7(46):75104-75117.
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