JG-98 |
| Katalog-Nr.GC34634 |
JG-98, ein Inhibitor des allosterischen Hitzeschockproteins 70 (Hsp70), der fest an eine konservierte Stelle auf Hsp70 bindet und die Hsp70-Bag3-Interaktion unterbricht. JG-98 zeigt Anti-Krebs-AktivitÄten, die sowohl Krebszellen als auch Tumor-assoziierte Makrophagen betreffen.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1456551-16-8
Sample solution is provided at 25 µL, 10mM.
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JG-98 is a heat shock protein 70 (Hsp70) Inhibitor with anti-cancer activities[1][2]. Heat shock protein 70[1]
JG-98 inhibits the breast cancer cell lines MDA-MB-231 and MCF-7 with EC50 values of 0.4 and 0.7 μM, respectively[1].
[1]. Yaglom JA, et al. Cancer cell responses to Hsp70 inhibitor JG-98: Comparison with Hsp90 inhibitors and findingsynergistic drug combinations. Sci Rep. 2018 Feb 14;8(1):3010.
Average Rating: 5 (Based on Reviews and 31 reference(s) in Google Scholar.)
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