Pentagastrin (ICI-50123) (Synonyms: AY 6608, NSC 367746) |
| Katalog-Nr.GC32776 |
Pentagastrin (ICI-50123) (ICI-50123) ist ein potenter, selektiver Cholecystokinin B (CCKB)-Rezeptorantagonist mit IC50-Werten von 11 nM und 1100 nM fÜr CCKB bzw. CCKA.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 5534-95-2
Sample solution is provided at 25 µL, 10mM.
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pentagastrin is a synthetic polypeptide that has effects like gastrin when given parenterally,which can cause the secretion and synthesis of salivary proteins.[1]In vivo: WIN55, 212-2, which is a non-selective cannabinoid agonist decreased gastric acid secretion stimulated by pentagastrin (10 mg/kg, i.v.) in anaesthetized rats.[2]The effect of curcumin administered i.g. in a dose of 50 mg/kg on the pentagastrin (250 ?g/kg)-stimulated gastric acid output in rats with chronic gastric fistula. [3]
[1]. Loy F et al. Ultrastructural evidence of a secretory role for melatonin in the human parotid gland.J Physiol Pharmacol, 2015 Dec, 66(6):847-53. [2]. Abdel-Salam O et al. Gastric acid inhibitory and gastric protective effects of Cannabis and cannabinoids. Asian Pac J Trop Med, 2016 May, 9(5):413-9. [3]. Czekaj R et al. Role of curcumin in protection of gastric mucosa against stress-induced gastric mucosal damage. Involvement of hypoacidity, vasoactive mediators and sensory neuropeptides. J Physiol Pharmacol, 2016 Apr, 67(2):261-75.
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