(S)-Verapamil hydrochloride |
Katalog-Nr.GC60008 |
(S)-Verapamilhydrochlorid (S(-)-Verapamilhydrochlorid) hemmt den Transport von Leukotrien C4 (LTC4) und Calcein durch MRP1. (S)-Verapamilhydrochlorid fÜhrt zum Absterben potenziell resistenter Tumorzellen.
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Cas No.: 36622-28-3
Sample solution is provided at 25 µL, 10mM.
(S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells[1].
(S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) not the (R)-Verapamil hydrochloride potently induces the death of MRP1-transfected BHK-21 cells[1]. (S)-Verapamil hydrochloride is good active form and has the low bioavailability[1].
[1]. Perrotton T, et al. (R)- and (S)-verapamil differentially modulate the multidrug-resistant protein MRP1. J Biol Chem. 2007 Oct 26;282(43):31542-8. Epub 2007 Jul 22. [2]. Tannergren C, et al. St John's wort decreases the bioavailability of R- and S-verapamil through induction of the first-pass metabolism. Clin Pharmacol Ther. 2004 Apr;75(4):298-309.
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